Automatic segmentation of nine retinal layer boundaries in OCT images of non-exudative AMD patients using deep learning and graph search

Leyuan Fang, David Cunefare, Chong Wang, Robyn H. Guymer, Shutao Li, Sina Farsiu

Research output: Contribution to journalArticleResearchpeer-review

420 Citations (Scopus)


We present a novel framework combining convolutional neural networks (CNN) and graph search methods (termed as CNN-GS) for the automatic segmentation of nine layer boundaries on retinal optical coherence tomography (OCT) images. CNN-GS first utilizes a CNN to extract features of specific retinal layer boundaries and train a corresponding classifier to delineate a pilot estimate of the eight layers. Next, a graph search method uses the probability maps created from the CNN to find the final boundaries. We validated our proposed method on 60 volumes (2915 B-scans) from 20 human eyes with non-exudative age-related macular degeneration (AMD), which attested to effectiveness of our proposed technique.

Original languageEnglish
Pages (from-to)2732-2744
Number of pages13
JournalBiomedical Optics Express
Issue number5
Publication statusPublished - 1 May 2017
Externally publishedYes


  • Image analysis
  • Image processing
  • Optical coherence tomography

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