Automatic renal interstitial fibrosis quantification system

Wei Keat Tey, Ye Chow Kuang, Joon Joon Khoo, Melanie Po Leen Ooi, Serge Demidenko

    Research output: Chapter in Book/Report/Conference proceedingConference PaperOther


    Interstitial fibrosis in renal biopsies has shown a good correlation to the presence of chronic kidney disease, and it is therefore quantified by pathologists in the diagnosis of the disease. In the previous work, the developed automatic quantification system for the interstitial fibrosis was presented. It was based on the segmentation of tubular structures. This paper advances the development of the system by expanding the set of identifiable structures to include glomerulus, arteries, and urinary casts. In particular, it investigates two methods of the glomerular detection, namely the Bowman's space search and rLADTree classification. The quantification results of the final system incorporating segmentation of all commonly seen structures have shown a quantification matching that produced by the ground truth to within 8.8%, while the glomerulus structure detection by rLADTree classification method outperformed its alternative due to its higher robustness in tolerating the variance in the glomerulus appearance.

    Original languageEnglish
    Title of host publicationI2MTC 2017 - 2017 IEEE International Instrumentation and Measurement Technology Conference, Proceedings
    PublisherIEEE, Institute of Electrical and Electronics Engineers
    ISBN (Electronic)9781509035960
    Publication statusPublished - 5 Jul 2017
    EventIEEE International Instrumentation and Measurement Technology Conference 2017 - Torino, Italy
    Duration: 22 May 201725 May 2017
    Conference number: 34th (Proceedings)


    ConferenceIEEE International Instrumentation and Measurement Technology Conference 2017
    Abbreviated titleI2MTC 2017
    Internet address


    • Glomerulus segmentation
    • Medical image analysis
    • Renal fibrosis
    • RLADTree

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