Automated non-invasive detection of pumping states in an implantable rotary blood pump

Dean M. Karantonis, Shaun L. Cloherty, David G. Mason, Robert F. Salamonsen, Peter J. Ayre, Nigel H. Lovell

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

8 Citations (Scopus)

Abstract

With respect to rotary blood pumps used as left ventricular assist devices (LVADs), it is clinically important to control pump flow to avoid complications associated with over-or under-pumping of the native heart By employing only the non-invasive observer of instantaneous pump impeller speed to assess flow dynamics, a number of physiologically significant pumping states may be detected. Based on a number of acute animal experiments, five such states were identified: regurgitant pump flow (PR), ventricular ejection (VE), non-opening of the aortic valve (ANO), and partial collapse (intermittent and continuous) of the ventricle wall (PVC-I and PVC-C. Two broader states, normal (corresponding to VE, ANO) and suction (corresponding to PVC-I, PVC-C were readily discernable in clinical data from human patients implanted with LVADs. Based on data from both the animal experiments (N = 6) and the human patients (N = 10), a strategy for the automated non-invasive detection of significant pumping states has been developed and validated. Employing a classification and regression tree (CART), this system detects pumping states with a high degree of accuracy: state VE -87.5/100.0% (sensitivity/specificity); state ANO - 98.1/92.5%; state PVC-I - 90.0/90.2%; state PVC-C - 61.2/98.0%. With a simplified binary scheme differentiating suction and normal states, both states were detected without error in data from the animal experiments, and with a sensitivity/specificity, for detecting suction, of 99.2/98.3% in the human patient data.
Original languageEnglish
Title of host publication2006 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vols 1-15
Pages4216-4219
Number of pages4
Publication statusPublished - 2006
Externally publishedYes
EventInternational Conference of the IEEE Engineering in Medicine and Biology Society 2006 - Marriott Hotel, New York, United States of America
Duration: 31 Aug 20063 Sep 2006
Conference number: 28th
https://ieeexplore.ieee.org/xpl/conhome/4028925/proceeding?isnumber=4461641 (Proceedings)

Conference

ConferenceInternational Conference of the IEEE Engineering in Medicine and Biology Society 2006
Abbreviated titleEMBC 2006
Country/TerritoryUnited States of America
CityNew York
Period31/08/063/09/06
Internet address

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