Automated differentiation of pre-diagnosis Huntington's disease from healthy control individuals based on quadratic discriminant analysis of the basal ganglia: the IMAGE-HD study

Nellie Georgiou-Karistianis; Marcus Gray; Juan F Dominguez; Alicia Rhian Dymowski; India Kate Bohanna; Leigh Andrea Johnston; Andrew J Churchyard; Phyllis Chua; Julie C Stout; Gary Francis Egan

doi:10.1016/j.nbd.2012.10.001

Automated differentiation of pre-diagnosis Huntington's disease from healthy control individuals based on quadratic discriminant analysis of the basal ganglia: the IMAGE-HD study

Nellie Georgiou-Karistianis, Marcus Gray, Juan F Dominguez, Alicia Rhian Dymowski, India Kate Bohanna, Leigh Andrea Johnston, Andrew J Churchyard, Phyllis Chua, Julie C Stout, Gary Francis Egan

Research output: Contribution to journal › Article › Research › peer-review

74 Citations (Scopus)

Abstract

We investigated two measures of neural integrity, T1-weighted volumetric measures and diffusion tensor imaging (DTI), and explored their combined potential to differentiate pre-diagnosis Huntington s disease (pre-HD) individuals from healthy controls.

Original language	English
Pages (from-to)	82 - 92
Number of pages	11
Journal	Neurobiology of Disease
Volume	51
DOIs	https://doi.org/10.1016/j.nbd.2012.10.001
Publication status	Published - 2013

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10.1016/j.nbd.2012.10.001

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Georgiou-Karistianis, N., Gray, M., Dominguez, J. F., Dymowski, A. R., Bohanna, I. K., Johnston, L. A., Churchyard, A. J., Chua, P., Stout, J. C., & Egan, G. F. (2013). Automated differentiation of pre-diagnosis Huntington's disease from healthy control individuals based on quadratic discriminant analysis of the basal ganglia: the IMAGE-HD study. Neurobiology of Disease, 51, 82 - 92. https://doi.org/10.1016/j.nbd.2012.10.001

@article{4f61f6ce7dfa412e8c23c06651105539,

title = "Automated differentiation of pre-diagnosis Huntington's disease from healthy control individuals based on quadratic discriminant analysis of the basal ganglia: the IMAGE-HD study",

abstract = "We investigated two measures of neural integrity, T1-weighted volumetric measures and diffusion tensor imaging (DTI), and explored their combined potential to differentiate pre-diagnosis Huntington s disease (pre-HD) individuals from healthy controls.",

author = "Nellie Georgiou-Karistianis and Marcus Gray and Dominguez, {Juan F} and Dymowski, {Alicia Rhian} and Bohanna, {India Kate} and Johnston, {Leigh Andrea} and Churchyard, {Andrew J} and Phyllis Chua and Stout, {Julie C} and Egan, {Gary Francis}",

year = "2013",

doi = "10.1016/j.nbd.2012.10.001",

language = "English",

volume = "51",

pages = "82 -- 92",

journal = "Neurobiology of Disease",

issn = "0969-9961",

publisher = "Academic Press",

}

Georgiou-Karistianis, N, Gray, M, Dominguez, JF, Dymowski, AR, Bohanna, IK, Johnston, LA, Churchyard, AJ, Chua, P, Stout, JC & Egan, GF 2013, 'Automated differentiation of pre-diagnosis Huntington's disease from healthy control individuals based on quadratic discriminant analysis of the basal ganglia: the IMAGE-HD study', Neurobiology of Disease, vol. 51, pp. 82 - 92. https://doi.org/10.1016/j.nbd.2012.10.001

Automated differentiation of pre-diagnosis Huntington's disease from healthy control individuals based on quadratic discriminant analysis of the basal ganglia: the IMAGE-HD study. / Georgiou-Karistianis, Nellie; Gray, Marcus; Dominguez, Juan F et al.
In: Neurobiology of Disease, Vol. 51, 2013, p. 82 - 92.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Automated differentiation of pre-diagnosis Huntington's disease from healthy control individuals based on quadratic discriminant analysis of the basal ganglia: the IMAGE-HD study

AU - Georgiou-Karistianis, Nellie

AU - Gray, Marcus

AU - Dominguez, Juan F

AU - Dymowski, Alicia Rhian

AU - Bohanna, India Kate

AU - Johnston, Leigh Andrea

AU - Churchyard, Andrew J

AU - Chua, Phyllis

AU - Stout, Julie C

AU - Egan, Gary Francis

PY - 2013

Y1 - 2013

N2 - We investigated two measures of neural integrity, T1-weighted volumetric measures and diffusion tensor imaging (DTI), and explored their combined potential to differentiate pre-diagnosis Huntington s disease (pre-HD) individuals from healthy controls.

AB - We investigated two measures of neural integrity, T1-weighted volumetric measures and diffusion tensor imaging (DTI), and explored their combined potential to differentiate pre-diagnosis Huntington s disease (pre-HD) individuals from healthy controls.

UR - http://www.sciencedirect.com/science/article/pii/S0969996112003294

U2 - 10.1016/j.nbd.2012.10.001

DO - 10.1016/j.nbd.2012.10.001

M3 - Article

SN - 0969-9961

VL - 51

SP - 82

EP - 92

JO - Neurobiology of Disease

JF - Neurobiology of Disease

ER -

Automated differentiation of pre-diagnosis Huntington's disease from healthy control individuals based on quadratic discriminant analysis of the basal ganglia: the IMAGE-HD study

Abstract

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A comparative cognitive and neuroimaging study of pre-diagnosis and symptomatic individuals with Huntington's disease

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Automated differentiation of pre-diagnosis Huntington's disease from healthy control individuals based on quadratic discriminant analysis of the basal ganglia: the IMAGE-HD study

Abstract

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A comparative cognitive and neuroimaging study of pre-diagnosis and symptomatic individuals with Huntington's disease

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