Autologous platelet-rich plasma for healing chronic venous leg ulcers

Clinical efficacy and potential mechanisms

Carolina D. Weller, Elizabeth E. Gardiner, Jane F. Arthur, Melissa Southey, Robert K. Andrews

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

The overall quality of evidence of autologous platelet-rich plasma (PRP) for treating chronic wounds remains low. While further well-designed clinical studies are clearly required to convincingly demonstrate the efficacy of autologous PRP in improved healing of venous leg ulcers (VLUs) and other chronic wounds, there is also an increasing need to better define the underlying mechanisms of action and whether positive outcomes can be predicted based on the analysis of PRP. This brief review will discuss the current understanding of autologous PRP in VLUs and whether molecular evaluation of PRP at the time of collection could potentially be informative to clinical outcomes. Benefits of the autologous PRP treatment strategy include that PRP is easily accessible and is relatively inexpensive and safe. Better understanding of the mechanisms involved could improve treatment, enable supplementation, and/or lead to gains in product development. Analysis of PRP could also add value to future clinical trials on efficacy and potentially personalised treatment regimens.

Original languageEnglish
Pages (from-to)788-792
Number of pages5
JournalInternational Wound Journal
Volume16
Issue number3
DOIs
Publication statusPublished - Jun 2019

Keywords

  • platelet glycoproteins
  • platelet physiology
  • wound healing

Cite this

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title = "Autologous platelet-rich plasma for healing chronic venous leg ulcers: Clinical efficacy and potential mechanisms",
abstract = "The overall quality of evidence of autologous platelet-rich plasma (PRP) for treating chronic wounds remains low. While further well-designed clinical studies are clearly required to convincingly demonstrate the efficacy of autologous PRP in improved healing of venous leg ulcers (VLUs) and other chronic wounds, there is also an increasing need to better define the underlying mechanisms of action and whether positive outcomes can be predicted based on the analysis of PRP. This brief review will discuss the current understanding of autologous PRP in VLUs and whether molecular evaluation of PRP at the time of collection could potentially be informative to clinical outcomes. Benefits of the autologous PRP treatment strategy include that PRP is easily accessible and is relatively inexpensive and safe. Better understanding of the mechanisms involved could improve treatment, enable supplementation, and/or lead to gains in product development. Analysis of PRP could also add value to future clinical trials on efficacy and potentially personalised treatment regimens.",
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Autologous platelet-rich plasma for healing chronic venous leg ulcers : Clinical efficacy and potential mechanisms. / Weller, Carolina D.; Gardiner, Elizabeth E.; Arthur, Jane F.; Southey, Melissa; Andrews, Robert K.

In: International Wound Journal, Vol. 16, No. 3, 06.2019, p. 788-792.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Autologous platelet-rich plasma for healing chronic venous leg ulcers

T2 - Clinical efficacy and potential mechanisms

AU - Weller, Carolina D.

AU - Gardiner, Elizabeth E.

AU - Arthur, Jane F.

AU - Southey, Melissa

AU - Andrews, Robert K.

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AB - The overall quality of evidence of autologous platelet-rich plasma (PRP) for treating chronic wounds remains low. While further well-designed clinical studies are clearly required to convincingly demonstrate the efficacy of autologous PRP in improved healing of venous leg ulcers (VLUs) and other chronic wounds, there is also an increasing need to better define the underlying mechanisms of action and whether positive outcomes can be predicted based on the analysis of PRP. This brief review will discuss the current understanding of autologous PRP in VLUs and whether molecular evaluation of PRP at the time of collection could potentially be informative to clinical outcomes. Benefits of the autologous PRP treatment strategy include that PRP is easily accessible and is relatively inexpensive and safe. Better understanding of the mechanisms involved could improve treatment, enable supplementation, and/or lead to gains in product development. Analysis of PRP could also add value to future clinical trials on efficacy and potentially personalised treatment regimens.

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