Autogenous transcriptional regulation of the regA gene, encoding an AraC-like, essential virulence regulator in Citrobacter rodentium

Aimee Tan; Ji Yang; Marija Tauschek; Judyta Praszkier; Roy Michael Robins-Browne

doi:10.1128/JB.01224-10

Autogenous transcriptional regulation of the regA gene, encoding an AraC-like, essential virulence regulator in Citrobacter rodentium

Aimee Tan
, Ji Yang
, Marija Tauschek
, Judyta Praszkier
, Roy Michael Robins-Browne

Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)

Abstract

We identified several promoters responsible for the expression of regA, which encodes a global virulence regulator in Citrobacter rodentium. Expression of some of the promoters was strongly autoactivated by RegA in conjunction with bicarbonate. Biochemical and mutational analyses were used to determine the consensus sequence of the RegA-binding sites.

Original language	English
Pages (from-to)	1777 - 1782
Number of pages	6
Journal	Journal of Bacteriology
Volume	193
Issue number	7
DOIs	https://doi.org/10.1128/JB.01224-10
Publication status	Published - 2011
Externally published	Yes

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title = "Autogenous transcriptional regulation of the regA gene, encoding an AraC-like, essential virulence regulator in Citrobacter rodentium",

abstract = "We identified several promoters responsible for the expression of regA, which encodes a global virulence regulator in Citrobacter rodentium. Expression of some of the promoters was strongly autoactivated by RegA in conjunction with bicarbonate. Biochemical and mutational analyses were used to determine the consensus sequence of the RegA-binding sites.",

author = "Aimee Tan and Ji Yang and Marija Tauschek and Judyta Praszkier and Robins-Browne, \{Roy Michael\}",

year = "2011",

doi = "10.1128/JB.01224-10",

language = "English",

volume = "193",

pages = "1777 -- 1782",

journal = "Journal of Bacteriology",

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T1 - Autogenous transcriptional regulation of the regA gene, encoding an AraC-like, essential virulence regulator in Citrobacter rodentium

AU - Tan, Aimee

AU - Yang, Ji

AU - Tauschek, Marija

AU - Praszkier, Judyta

AU - Robins-Browne, Roy Michael

PY - 2011

Y1 - 2011

N2 - We identified several promoters responsible for the expression of regA, which encodes a global virulence regulator in Citrobacter rodentium. Expression of some of the promoters was strongly autoactivated by RegA in conjunction with bicarbonate. Biochemical and mutational analyses were used to determine the consensus sequence of the RegA-binding sites.

AB - We identified several promoters responsible for the expression of regA, which encodes a global virulence regulator in Citrobacter rodentium. Expression of some of the promoters was strongly autoactivated by RegA in conjunction with bicarbonate. Biochemical and mutational analyses were used to determine the consensus sequence of the RegA-binding sites.

UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067653/pdf/1224-10.pdf

U2 - 10.1128/JB.01224-10

DO - 10.1128/JB.01224-10

M3 - Article

SN - 0021-9193

VL - 193

SP - 1777

EP - 1782

JO - Journal of Bacteriology

JF - Journal of Bacteriology

IS - 7

ER -

Autogenous transcriptional regulation of the regA gene, encoding an AraC-like, essential virulence regulator in Citrobacter rodentium

Abstract

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