TY - JOUR
T1 - Autobiographical narratives relate to Alzheimer's disease biomarkers in older adults
AU - Buckley, Rachel F.
AU - Saling, Michael M.
AU - Irish, Muireann
AU - Ames, David
AU - Rowe, Christopher C.
AU - Villemagne, Victor L.
AU - Lautenschlager, Nicola T.
AU - Maruff, Paul
AU - Macaulay, S. Lance
AU - Martins, Ralph N.
AU - Szoeke, Cassandra
AU - Masters, Colin L.
AU - Rainey-Smith, Stephanie R.
AU - Rembach, Alan
AU - Savage, Greg
AU - Ellis, Kathryn A.
AU - the Australian Imaging Biomarkers and Lifestyle (AIBL) Research Group
N1 - Publisher Copyright:
© International Psychogeriatric Association 2014.
PY - 2014/10
Y1 - 2014/10
N2 - Background: Autobiographical memory (ABM), personal semantic memory (PSM), and autonoetic consciousness are affected in individuals with mild cognitive impairment (MCI) but their relationship with Alzheimer's disease (AD) biomarkers are unclear. Methods: Forty-five participants (healthy controls (HC) = 31, MCI = 14) completed the Episodic ABM Interview and a battery of memory tests. Thirty-one (HC = 22, MCI = 9) underwent β-amyloid positron emission tomography (PET) and magnetic resonance (MR) imaging. Fourteen participants (HC = 9, MCI = 5) underwent one imaging modality. Results: Unlike PSM, ABM differentiated between diagnostic categories but did not relate to AD biomarkers. Personal semantic memory was related to neocortical β-amyloid burden after adjusting for age and apolipoprotein E (APOE) É4. Autonoetic consciousness was not associated with AD biomarkers, and was not impaired in MCI. Conclusions: Autobiographical memory was impaired in MCI participants but was not related to neocortical amyloid burden, suggesting that personal memory systems are impacted by differing disease mechanisms, rather than being uniformly underpinned by β-amyloid. Episodic and semantic ABM impairment represent an important AD prodrome.
AB - Background: Autobiographical memory (ABM), personal semantic memory (PSM), and autonoetic consciousness are affected in individuals with mild cognitive impairment (MCI) but their relationship with Alzheimer's disease (AD) biomarkers are unclear. Methods: Forty-five participants (healthy controls (HC) = 31, MCI = 14) completed the Episodic ABM Interview and a battery of memory tests. Thirty-one (HC = 22, MCI = 9) underwent β-amyloid positron emission tomography (PET) and magnetic resonance (MR) imaging. Fourteen participants (HC = 9, MCI = 5) underwent one imaging modality. Results: Unlike PSM, ABM differentiated between diagnostic categories but did not relate to AD biomarkers. Personal semantic memory was related to neocortical β-amyloid burden after adjusting for age and apolipoprotein E (APOE) É4. Autonoetic consciousness was not associated with AD biomarkers, and was not impaired in MCI. Conclusions: Autobiographical memory was impaired in MCI participants but was not related to neocortical amyloid burden, suggesting that personal memory systems are impacted by differing disease mechanisms, rather than being uniformly underpinned by β-amyloid. Episodic and semantic ABM impairment represent an important AD prodrome.
KW - autobiographical memory
KW - hippocampal volume
KW - mild cognitive impairment
KW - β-amyloid
UR - http://www.scopus.com/inward/record.url?scp=84931571275&partnerID=8YFLogxK
U2 - 10.1017/S1041610214001136
DO - 10.1017/S1041610214001136
M3 - Article
C2 - 24969443
AN - SCOPUS:84931571275
SN - 1041-6102
VL - 26
SP - 1737
EP - 1746
JO - International Psychogeriatrics
JF - International Psychogeriatrics
IS - 10
ER -