Author Response: Utility of Acute and Subacute Blood Biomarkers to Assist Diagnosis in CT-Negative Isolated Mild Traumatic Brain Injury

Stuart J. McDonald; Jonathan Reyes; Gershon Spitz; Lauren P. Giesler; Sandy Shultz; Biswadev Mitra

doi:10.1212/WNL.0000000000209411

Author Response: Utility of Acute and Subacute Blood Biomarkers to Assist Diagnosis in CT-Negative Isolated Mild Traumatic Brain Injury

Stuart J. McDonald, Jonathan Reyes, Gershon Spitz, Lauren P. Giesler, Sandy Shultz, Biswadev Mitra

Research output: Contribution to journal › Letter › Other › peer-review

Abstract

We appreciate the interest of Lampros et al. in our article1 and their insightful comments regarding the potential of the neutrophil-to-lymphocyte ratio (NLR) in mild traumatic brain injury (mTBI). The NLR holds promise as a relatively low-cost and more readily available biomarker of inflammation compared with immunoassay measures of interleukin-6 (IL-6). While we cannot explore the potential diagnostic utility of the NLR because of the absence of this measure in our control participants, acute NLR data were available for 37 of the 74 patients with mTBI. As such, in response to the suggestion provided by Lampros et al., we have analyzed NLR values and their correlation with acute IL-6 values in this subgroup.

Original language	English
Article number	e209411
Number of pages	1
Journal	Neurology
Volume	103
Issue number	3
DOIs	https://doi.org/10.1212/WNL.0000000000209411
Publication status	Published - 3 Jul 2024

Access to Document

10.1212/WNL.0000000000209411

Cite this

@article{4cb4bb1306e74439bd479f5084c4eea3,

title = "Author Response: Utility of Acute and Subacute Blood Biomarkers to Assist Diagnosis in CT-Negative Isolated Mild Traumatic Brain Injury",

abstract = "We appreciate the interest of Lampros et al. in our article1 and their insightful comments regarding the potential of the neutrophil-to-lymphocyte ratio (NLR) in mild traumatic brain injury (mTBI). The NLR holds promise as a relatively low-cost and more readily available biomarker of inflammation compared with immunoassay measures of interleukin-6 (IL-6). While we cannot explore the potential diagnostic utility of the NLR because of the absence of this measure in our control participants, acute NLR data were available for 37 of the 74 patients with mTBI. As such, in response to the suggestion provided by Lampros et al., we have analyzed NLR values and their correlation with acute IL-6 values in this subgroup.",

author = "McDonald, {Stuart J.} and Jonathan Reyes and Gershon Spitz and Giesler, {Lauren P.} and Sandy Shultz and Biswadev Mitra",

note = "Publisher Copyright: {\textcopyright} American Academy of Neurology.",

year = "2024",

month = jul,

day = "3",

doi = "10.1212/WNL.0000000000209411",

language = "English",

volume = "103",

journal = "Neurology",

issn = "0028-3878",

publisher = "Ovid Technologies (Wolters Kluwer) - American Academy of Neurology",

number = "3",

}

TY - JOUR

T1 - Author Response

T2 - Utility of Acute and Subacute Blood Biomarkers to Assist Diagnosis in CT-Negative Isolated Mild Traumatic Brain Injury

AU - McDonald, Stuart J.

AU - Reyes, Jonathan

AU - Spitz, Gershon

AU - Giesler, Lauren P.

AU - Shultz, Sandy

AU - Mitra, Biswadev

PY - 2024/7/3

Y1 - 2024/7/3

N2 - We appreciate the interest of Lampros et al. in our article1 and their insightful comments regarding the potential of the neutrophil-to-lymphocyte ratio (NLR) in mild traumatic brain injury (mTBI). The NLR holds promise as a relatively low-cost and more readily available biomarker of inflammation compared with immunoassay measures of interleukin-6 (IL-6). While we cannot explore the potential diagnostic utility of the NLR because of the absence of this measure in our control participants, acute NLR data were available for 37 of the 74 patients with mTBI. As such, in response to the suggestion provided by Lampros et al., we have analyzed NLR values and their correlation with acute IL-6 values in this subgroup.

AB - We appreciate the interest of Lampros et al. in our article1 and their insightful comments regarding the potential of the neutrophil-to-lymphocyte ratio (NLR) in mild traumatic brain injury (mTBI). The NLR holds promise as a relatively low-cost and more readily available biomarker of inflammation compared with immunoassay measures of interleukin-6 (IL-6). While we cannot explore the potential diagnostic utility of the NLR because of the absence of this measure in our control participants, acute NLR data were available for 37 of the 74 patients with mTBI. As such, in response to the suggestion provided by Lampros et al., we have analyzed NLR values and their correlation with acute IL-6 values in this subgroup.

UR - http://www.scopus.com/inward/record.url?scp=85197732895&partnerID=8YFLogxK

U2 - 10.1212/WNL.0000000000209411

DO - 10.1212/WNL.0000000000209411

M3 - Letter

C2 - 38959459

AN - SCOPUS:85197732895

SN - 0028-3878

VL - 103

JO - Neurology

JF - Neurology

IS - 3

M1 - e209411

ER -

Author Response: Utility of Acute and Subacute Blood Biomarkers to Assist Diagnosis in CT-Negative Isolated Mild Traumatic Brain Injury

Abstract

Access to Document

Other files and links

Research output

Utility of Acute and Subacute Blood Biomarkers to Assist Diagnosis in CT-Negative Isolated Mild Traumatic Brain Injury

Cite this