Projects per year
Biological and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARD) have been an important advance in the management of inflammatory arthritis, but are expensive medications, carry a risk of infection and other adverse effects, and are often perceived as a burden by patients. We used GRADE methodology to develop recommendations for dose reduction and discontinuation of b/tsDMARD in people with rheumatoid arthritis (RA), axial spondyloarthritis (AxSpA) and psoriatic arthritis (PsA) who have achieved a low disease activity state or remission. The recommendations form part of the Australian Living Guideline for the Pharmacological Management of Inflammatory Arthritis, an NHMRC-endorsed ‘living’ guideline, in which recommendations are updated in near real-time as new evidence emerges. Conditional recommendations were made in favour of dose reduction in RA and AxSpA but not in PsA. Abrupt discontinuation of b/tsDMARD is not recommended in any of the three diseases.
1/01/21 → 31/12/25
Buchbinder, R., Maher, C., March, L. M., Day, R. O., Hinman, R. S., Harris, I. A., Ferreira, M., Glaziou, P., Green, S., Billot, L., Latimer, J., Whittle, S. L., Cicuttini, F., Hill, C. L., Lin, C., Taylor, W. J., Hunter, D., Harris, A., Winzenberg, T. M. & McAuley, J.
1/01/18 → 31/12/22