Auditory P300 studies in schizophrenic subjects and their first degree relatives

John L. Black, Bryan J. Mowry, David A. Barton, John N. De Roach

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Nineteen subjects with schizophrenia, 6 subjects with related disorders (schizophrenic spectrum disorders (S.S.D.)), and 20 unaffected first degree relatives from a sample of schizophrenic pedigrees, together with 35 normal control subjects, had auditory P300 evoked responses measured, using the 'odd-ball' paradigm for stimulation. Bipolar recording on the midline (C2O2) and two contralateral sites (C2-mastoid) was carried out. It was found that approximately 40% of schizophrenics/S.S.D.'s had abnormal P300 responses. Abnormalities were seen in latency, RMS response voltage and in the left side response - right side response cross correlation coefficient. Schizophrenics/S.S.D.s showed responses which were topographically different than those of normal controls. Significant left-side/right-side response voltage asymmetry was not observed. In our study, only 10% of unaffected relatives of schizophrenics/S.S.D.'s showed abnormal P300 responses.

Original languageEnglish
Pages (from-to)65-73
Number of pages9
JournalAustralasian Physical and Engineering Sciences in Medicine
Issue number2
Publication statusPublished - 1 Jun 1992
Externally publishedYes

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