Projects per year
The capacity of the brain to encode multiple types of sensory input is key to survival. Yet, how neurons integrate information from multiple sensory pathways and to what extent this influences behavior is largely unknown. Using two-photon Ca2+ imaging, optogenetics and electrophysiology in vivo and in vitro, we report the influence of auditory input on sensory encoding in the somatosensory cortex and show its impact on goal-directed behavior. Monosynaptic input from the auditory cortex enhanced dendritic and somatic encoding of tactile stimulation in layer 2/3 (L2/3), but not layer 5 (L5), pyramidal neurons in forepaw somatosensory cortex (S1). During a tactile-based goal-directed task, auditory input increased dendritic activity and reduced reaction time, which was abolished by photoinhibition of auditory cortex projections to forepaw S1. Taken together, these results indicate that dendrites of L2/3 pyramidal neurons encode multisensory information, leading to enhanced neuronal output and reduced response latency during goal-directed behavior.
- 1 Finished
Egan, G., Rosa, M., Lowery, A., Stuart, G., Arabzadeh, E., Skafidas, E., Ibbotson, M., Petrou, S., Paxinos, G., Mattingley, J., Garrido, M., Sah, P., Robinson, P. A., Martin, P., Grunert, U., Tanaka, K., Mitra, P., Johnson, G., Diamond, M., Margrie, T., Leopold, D., Movshon, J., Markram, H., Victor, J., Hill, S. & Jirsa, V.
Australian National University (ANU), Eidgenössische Technische Hochschule Zürich (ETH Zurich), Australian Research Council (ARC), Karolinska Institutet (Karolinska Institute), QIMR Berghofer Medical Research Institute, Ecole Polytechnique Federale de Lausanne (EPFL) (Swiss Federal Institute of Technology in Lausanne) , Monash University, University of Melbourne, University of New South Wales (UNSW), University of Queensland , University of Sydney, Monash University – Internal University Contribution, NIH - National Institutes of Health (United States of America), Cornell University, New York University, MRC National Institute for Medical Research, Scuola Internazionale Superiore di Studi Avanzati (International School for Advanced Studies), Duke University, Cold Spring Harbor Laboratory, RIKEN
25/06/14 → 31/12/21