Atypical TGF-β signaling controls neuronal guidance in Caenorhabditis elegans

Oguzhan Baltaci, Mikael Egebjerg Pedersen, Tessa Sherry, Ava Handley, Goda Snieckute, Wei Cao, Matilda Haas, Stuart Archer, Roger Pocock

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)


Coordinated expression of cell adhesion and signaling molecules is crucial for brain development. Here, we report that the Caenorhabditis elegans transforming growth factor β (TGF-β) type I receptor SMA-6 (small-6) acts independently of its cognate TGF-β type II receptor DAF-4 (dauer formation-defective-4) to control neuronal guidance. SMA-6 directs neuronal development from the hypodermis through interactions with three, orphan, TGF-β ligands. Intracellular signaling downstream of SMA-6 limits expression of NLR-1, an essential Neurexin-like cell adhesion receptor, to enable neuronal guidance. Together, our data identify an atypical TGF-β-mediated regulatory mechanism to ensure correct neuronal development.

Original languageEnglish
Article number103791
Number of pages17
Issue number2
Publication statusPublished - 18 Feb 2022


  • Biological sciences
  • Developmental neuroscience
  • Molecular neuroscience

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