Atypical TGF-β signaling controls neuronal guidance in Caenorhabditis elegans

Oguzhan Baltaci; Mikael Egebjerg Pedersen; Tessa Sherry; Ava Handley; Goda Snieckute; Wei Cao; Matilda Haas; Stuart Archer; Roger Pocock

doi:10.1016/j.isci.2022.103791

Atypical TGF-β signaling controls neuronal guidance in Caenorhabditis elegans

Oguzhan Baltaci, Mikael Egebjerg Pedersen, Tessa Sherry, Ava Handley, Goda Snieckute, Wei Cao, Matilda Haas, Stuart Archer, Roger Pocock

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

Abstract

Coordinated expression of cell adhesion and signaling molecules is crucial for brain development. Here, we report that the Caenorhabditis elegans transforming growth factor β (TGF-β) type I receptor SMA-6 (small-6) acts independently of its cognate TGF-β type II receptor DAF-4 (dauer formation-defective-4) to control neuronal guidance. SMA-6 directs neuronal development from the hypodermis through interactions with three, orphan, TGF-β ligands. Intracellular signaling downstream of SMA-6 limits expression of NLR-1, an essential Neurexin-like cell adhesion receptor, to enable neuronal guidance. Together, our data identify an atypical TGF-β-mediated regulatory mechanism to ensure correct neuronal development.

Original language	English
Article number	103791
Number of pages	17
Journal	iScience
Volume	25
Issue number	2
DOIs	https://doi.org/10.1016/j.isci.2022.103791
Publication status	Published - 18 Feb 2022

Keywords

Biological sciences
Developmental neuroscience
Molecular neuroscience

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10.1016/j.isci.2022.103791Licence: CC BY-NC-ND

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title = "Atypical TGF-β signaling controls neuronal guidance in Caenorhabditis elegans",

abstract = "Coordinated expression of cell adhesion and signaling molecules is crucial for brain development. Here, we report that the Caenorhabditis elegans transforming growth factor β (TGF-β) type I receptor SMA-6 (small-6) acts independently of its cognate TGF-β type II receptor DAF-4 (dauer formation-defective-4) to control neuronal guidance. SMA-6 directs neuronal development from the hypodermis through interactions with three, orphan, TGF-β ligands. Intracellular signaling downstream of SMA-6 limits expression of NLR-1, an essential Neurexin-like cell adhesion receptor, to enable neuronal guidance. Together, our data identify an atypical TGF-β-mediated regulatory mechanism to ensure correct neuronal development.",

keywords = "Biological sciences, Developmental neuroscience, Molecular neuroscience",

author = "Oguzhan Baltaci and Pedersen, {Mikael Egebjerg} and Tessa Sherry and Ava Handley and Goda Snieckute and Wei Cao and Matilda Haas and Stuart Archer and Roger Pocock",

note = "Funding Information: We thank members of Pocock laboratory and Brent Neumann for comments on the manuscript. Some strains used in this study were provided by the Caenorhabditis Genetics Center, which is funded by NIH Office of Research Infrastructure Programs ( P40 OD010440 ), and by Shohei Mitani at the National Bioresource Project (Japan). We also thank Rick Padgett for the elt-3p::sma-6::gfp plasmid, Jun Liu for the Myc-SMA-6 plasmid, Yuichi Iino for the rimb-1 promoter, and Yun Zhang for the sma-6(wk7); ges-1p::sma-6, and sma-6(wk7); sma-6p::sma-6 rescue strains. The authors also acknowledge use of the services and facilities of Micromon Genomics at Monash University . Funding: This work was supported by a grant from the European Research Council (ERC Starting Grant number 260807 ), Monash Biomedicine Discovery Fellowship , NHMRC Project Grant ( GNT1105374 ), NHMRC Senior Research Fellowship ( GNT1137645 ), and a Victorian Endowment for Science, Knowledge and Innovation Fellowship ( VIF23 ) to R.P. Publisher Copyright: {\textcopyright} 2022 The Author(s)",

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AU - Baltaci, Oguzhan

AU - Pedersen, Mikael Egebjerg

AU - Sherry, Tessa

AU - Handley, Ava

AU - Snieckute, Goda

AU - Cao, Wei

AU - Haas, Matilda

AU - Archer, Stuart

AU - Pocock, Roger

N1 - Funding Information: We thank members of Pocock laboratory and Brent Neumann for comments on the manuscript. Some strains used in this study were provided by the Caenorhabditis Genetics Center, which is funded by NIH Office of Research Infrastructure Programs ( P40 OD010440 ), and by Shohei Mitani at the National Bioresource Project (Japan). We also thank Rick Padgett for the elt-3p::sma-6::gfp plasmid, Jun Liu for the Myc-SMA-6 plasmid, Yuichi Iino for the rimb-1 promoter, and Yun Zhang for the sma-6(wk7); ges-1p::sma-6, and sma-6(wk7); sma-6p::sma-6 rescue strains. The authors also acknowledge use of the services and facilities of Micromon Genomics at Monash University . Funding: This work was supported by a grant from the European Research Council (ERC Starting Grant number 260807 ), Monash Biomedicine Discovery Fellowship , NHMRC Project Grant ( GNT1105374 ), NHMRC Senior Research Fellowship ( GNT1137645 ), and a Victorian Endowment for Science, Knowledge and Innovation Fellowship ( VIF23 ) to R.P. Publisher Copyright: © 2022 The Author(s)

PY - 2022/2/18

Y1 - 2022/2/18

N2 - Coordinated expression of cell adhesion and signaling molecules is crucial for brain development. Here, we report that the Caenorhabditis elegans transforming growth factor β (TGF-β) type I receptor SMA-6 (small-6) acts independently of its cognate TGF-β type II receptor DAF-4 (dauer formation-defective-4) to control neuronal guidance. SMA-6 directs neuronal development from the hypodermis through interactions with three, orphan, TGF-β ligands. Intracellular signaling downstream of SMA-6 limits expression of NLR-1, an essential Neurexin-like cell adhesion receptor, to enable neuronal guidance. Together, our data identify an atypical TGF-β-mediated regulatory mechanism to ensure correct neuronal development.

AB - Coordinated expression of cell adhesion and signaling molecules is crucial for brain development. Here, we report that the Caenorhabditis elegans transforming growth factor β (TGF-β) type I receptor SMA-6 (small-6) acts independently of its cognate TGF-β type II receptor DAF-4 (dauer formation-defective-4) to control neuronal guidance. SMA-6 directs neuronal development from the hypodermis through interactions with three, orphan, TGF-β ligands. Intracellular signaling downstream of SMA-6 limits expression of NLR-1, an essential Neurexin-like cell adhesion receptor, to enable neuronal guidance. Together, our data identify an atypical TGF-β-mediated regulatory mechanism to ensure correct neuronal development.

KW - Biological sciences

KW - Developmental neuroscience

KW - Molecular neuroscience

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DO - 10.1016/j.isci.2022.103791

M3 - Article

AN - SCOPUS:85123846562

VL - 25

JO - iScience

JF - iScience

SN - 2589-0042

IS - 2

M1 - 103791

ER -

Atypical TGF-β signaling controls neuronal guidance in Caenorhabditis elegans

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Decoding mechanisms of brain-intestinal communication

Decoding Conserved Mechanisms That Control Neuronal Migration

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Atypical TGF-β signaling controls neuronal guidance in Caenorhabditis elegans

Abstract

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Decoding mechanisms of brain-intestinal communication

Decoding Conserved Mechanisms That Control Neuronal Migration

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Micromon

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