Atypical Spitzoid neoplasms: A review of potential markers of biological behavior including sentinel node biopsy

Christopher J. McCormack, Rachel K. Conyers, Richard A. Scolyer, John Kirkwood, David Speakman, Nick Wong, John W. Kelly, Michael A. Henderson

Research output: Contribution to journalReview ArticleResearchpeer-review

20 Citations (Scopus)


Atypical cutaneous melanocytic lesions, including those with Spitzoid features, can be difficult to categorize as benign or malignant. This can lead to suboptimal management, with potential adverse patient outcomes. Recent studies have enhanced knowledge of the molecular and genetic biology of these lesions and, combined with clinicopathological findings, is further defining their biological spectrum, classification, and behavior. Sentinel node biopsy provides important prognostic information in patients with cutaneous melanoma, but its role in the management of melanocytic lesions of uncertain malignant potential (MELTUMP) is controversial. This paper examines the role of molecular testing and sentinel node biopsy in MELTUMPs, particularly atypical Spitzoid tumors.

Original languageEnglish
Pages (from-to)437-447
Number of pages11
JournalMelanoma Research
Issue number5
Publication statusPublished - 1 Oct 2014
Externally publishedYes


  • Melanocytic lesions of uncertain malignant potential
  • Melanoma
  • Sentinel node biopsy
  • Spitz nevi
  • Spitzoid

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