TY - JOUR
T1 - Atypical (RIO) protein kinases from Haemonchus contortus - promise as new targets for nematocidal drugs
AU - Campbell, Bronwyn
AU - Boag, Peter R
AU - Hofmann, Andreas
AU - Cantacessi, Cinzia
AU - Wang, Conan K
AU - Taylor, Paul
AU - Hu, Min
AU - Sindhu, Zia-ud-Din
AU - Loukas, Alex
AU - Sternberg, Paul W
AU - Gasser, Robin B
PY - 2011
Y1 - 2011
N2 - Almost nothing is known about atypical kinases in multicellular organisms, including parasites. Supported by information and data available for the free-living nematode, Caenorhabditis elegans, and other eukaryotes, the present article describes three RIO kinase genes, riok-1, riok-2 and riok-3, from Haemonchus contortus, one of the most important parasitic nematodes of small ruminants. Analyses of these genes and their products predict that they each play critical roles in the developmental pathways of parasitic nematodes. The findings of this review indicate prospects for functional studies of these genes in C. elegans (as a surrogate) and opportunities for the design of a novel class of nematode-specific inhibitors of RIO kinases. The latter aspect is of paramount importance, given the serious problems linked to antihelmintic resistance in parasitic nematode populations of livestock.
AB - Almost nothing is known about atypical kinases in multicellular organisms, including parasites. Supported by information and data available for the free-living nematode, Caenorhabditis elegans, and other eukaryotes, the present article describes three RIO kinase genes, riok-1, riok-2 and riok-3, from Haemonchus contortus, one of the most important parasitic nematodes of small ruminants. Analyses of these genes and their products predict that they each play critical roles in the developmental pathways of parasitic nematodes. The findings of this review indicate prospects for functional studies of these genes in C. elegans (as a surrogate) and opportunities for the design of a novel class of nematode-specific inhibitors of RIO kinases. The latter aspect is of paramount importance, given the serious problems linked to antihelmintic resistance in parasitic nematode populations of livestock.
UR - http://www.ncbi.nlm.nih.gov/pubmed/21262337
U2 - 10.1016/j.biotechadv.2011.01.006
DO - 10.1016/j.biotechadv.2011.01.006
M3 - Article
SN - 0734-9750
VL - 29
SP - 338
EP - 350
JO - Biotechnology Advances
JF - Biotechnology Advances
IS - 3
ER -