Atypical interference control in children with AD/HD with elevated theta/beta ratio

Da Wei Zhang; Steven Roodenrys; Hui Li; Robert J. Barry; Adam R. Clarke; Zhanliang Wu; Qihua Zhao; Yan Song; Lu Liu; Qiujin Qian; Yufeng Wang; Stuart J. Johnstone; Li Sun

doi:10.1016/j.biopsycho.2017.07.009

Atypical interference control in children with AD/HD with elevated theta/beta ratio

Da Wei Zhang, Steven Roodenrys, Hui Li, Robert J. Barry, Adam R. Clarke, Zhanliang Wu, Qihua Zhao, Yan Song, Lu Liu, Qiujin Qian, Yufeng Wang, Stuart J. Johnstone, Li Sun

Research output: Contribution to journal › Article › Research › peer-review

27 Citations (Scopus)

Abstract

The theta/beta ratio (TBR) is a major area of interest within electroencephalogram (EEG) research in AD/HD. While researchers suggest a prognostic role for TBR in AD/HD, its relationship to behavior remains uncertain. Recent evidence suggests that elevated TBR in AD/HD may be related to atypical inhibition, particularly at an attentional level. This study aimed to examine the performance on three inhibitory tasks of children with AD/HD. Fifty-eight children with AD/HD participated, divided into an elevated TBR (ET) group and a control group (CT). A behavioral disassociation was found − compared to CT, ET showed more difficulty in inhibiting surrounding stimuli but had less day-to-day inhibitory issues measured by BRIEF. There was no significant group difference on response inhibition. The results support the prognostic value of TBR in AD/HD. Elevated TBR may be an inhibitory biomarker; further studies are needed to explore the behavioral implications in patients without elevated TBR.

Original language	English
Pages (from-to)	82-88
Number of pages	7
Journal	Biological Psychology
Volume	128
DOIs	https://doi.org/10.1016/j.biopsycho.2017.07.009
Publication status	Published - Sept 2017
Externally published	Yes

Keywords

AD/HD
Biomarker
EEG
Inhibition
Interference control
Theta/beta ratio

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10.1016/j.biopsycho.2017.07.009

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@article{1c90634f70524a259ecaeb8ffbfd9697,

title = "Atypical interference control in children with AD/HD with elevated theta/beta ratio",

abstract = "The theta/beta ratio (TBR) is a major area of interest within electroencephalogram (EEG) research in AD/HD. While researchers suggest a prognostic role for TBR in AD/HD, its relationship to behavior remains uncertain. Recent evidence suggests that elevated TBR in AD/HD may be related to atypical inhibition, particularly at an attentional level. This study aimed to examine the performance on three inhibitory tasks of children with AD/HD. Fifty-eight children with AD/HD participated, divided into an elevated TBR (ET) group and a control group (CT). A behavioral disassociation was found − compared to CT, ET showed more difficulty in inhibiting surrounding stimuli but had less day-to-day inhibitory issues measured by BRIEF. There was no significant group difference on response inhibition. The results support the prognostic value of TBR in AD/HD. Elevated TBR may be an inhibitory biomarker; further studies are needed to explore the behavioral implications in patients without elevated TBR.",

keywords = "AD/HD, Biomarker, EEG, Inhibition, Interference control, Theta/beta ratio",

author = "Zhang, {Da Wei} and Steven Roodenrys and Hui Li and Barry, {Robert J.} and Clarke, {Adam R.} and Zhanliang Wu and Qihua Zhao and Yan Song and Lu Liu and Qiujin Qian and Yufeng Wang and Johnstone, {Stuart J.} and Li Sun",

note = "Funding Information: Funding: This work was funded by the National Basic Research Program of China (2014CB846104), the National Key Technology R&D Program (2015BAI13B01), and the National Natural Science Foundation of China (81371496). The Chinese Scholarship Council provided a scholarship for D-W Zhang. Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

year = "2017",

month = sep,

doi = "10.1016/j.biopsycho.2017.07.009",

language = "English",

volume = "128",

pages = "82--88",

journal = "Biological Psychology",

issn = "0301-0511",

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T1 - Atypical interference control in children with AD/HD with elevated theta/beta ratio

AU - Zhang, Da Wei

AU - Roodenrys, Steven

AU - Li, Hui

AU - Barry, Robert J.

AU - Clarke, Adam R.

AU - Wu, Zhanliang

AU - Zhao, Qihua

AU - Song, Yan

AU - Liu, Lu

AU - Qian, Qiujin

AU - Wang, Yufeng

AU - Johnstone, Stuart J.

AU - Sun, Li

N1 - Funding Information: Funding: This work was funded by the National Basic Research Program of China (2014CB846104), the National Key Technology R&D Program (2015BAI13B01), and the National Natural Science Foundation of China (81371496). The Chinese Scholarship Council provided a scholarship for D-W Zhang. Publisher Copyright: © 2017 Elsevier B.V.

PY - 2017/9

Y1 - 2017/9

N2 - The theta/beta ratio (TBR) is a major area of interest within electroencephalogram (EEG) research in AD/HD. While researchers suggest a prognostic role for TBR in AD/HD, its relationship to behavior remains uncertain. Recent evidence suggests that elevated TBR in AD/HD may be related to atypical inhibition, particularly at an attentional level. This study aimed to examine the performance on three inhibitory tasks of children with AD/HD. Fifty-eight children with AD/HD participated, divided into an elevated TBR (ET) group and a control group (CT). A behavioral disassociation was found − compared to CT, ET showed more difficulty in inhibiting surrounding stimuli but had less day-to-day inhibitory issues measured by BRIEF. There was no significant group difference on response inhibition. The results support the prognostic value of TBR in AD/HD. Elevated TBR may be an inhibitory biomarker; further studies are needed to explore the behavioral implications in patients without elevated TBR.

AB - The theta/beta ratio (TBR) is a major area of interest within electroencephalogram (EEG) research in AD/HD. While researchers suggest a prognostic role for TBR in AD/HD, its relationship to behavior remains uncertain. Recent evidence suggests that elevated TBR in AD/HD may be related to atypical inhibition, particularly at an attentional level. This study aimed to examine the performance on three inhibitory tasks of children with AD/HD. Fifty-eight children with AD/HD participated, divided into an elevated TBR (ET) group and a control group (CT). A behavioral disassociation was found − compared to CT, ET showed more difficulty in inhibiting surrounding stimuli but had less day-to-day inhibitory issues measured by BRIEF. There was no significant group difference on response inhibition. The results support the prognostic value of TBR in AD/HD. Elevated TBR may be an inhibitory biomarker; further studies are needed to explore the behavioral implications in patients without elevated TBR.

KW - AD/HD

KW - Biomarker

KW - EEG

KW - Inhibition

KW - Interference control

KW - Theta/beta ratio

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SN - 0301-0511

VL - 128

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JO - Biological Psychology

JF - Biological Psychology

ER -

Atypical interference control in children with AD/HD with elevated theta/beta ratio

Abstract

Keywords

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