Attenuated methacholine airway response following repeat testing in a murine model of allergic airways disease

Ross McKenzie, Simon G. Royce, Matthew D. Burton, Mimi L. K. Tang

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

A progressive attenuation of airway reactivity to methacholine is observed in normal individuals with successive bronchial provocation testing. The absence of this attenuation in asthma is thought to be due airway inflammation. The authors investigated this phenomenon in a mouse model of allergic airways disease. Repeated measurements of airway response were carried out in mice sensitized/challenged with ovalbumin or saline, and in untreated mice. Saline-treated and untreated mice showed reduced airway reactivity following repeated testing. This was also observed in ovalbumin-treated mice in the second and third tests compared to the previous test (P

Original languageEnglish
Pages (from-to)277-286
Number of pages10
JournalExperimental Lung Research
Volume34
Issue number5
DOIs
Publication statusPublished - Jun 2008
Externally publishedYes

Keywords

  • Airway reactivity
  • Asthma
  • Attenuation
  • Balb/c
  • Lung
  • Methacholine
  • Mice
  • Penh
  • Tachyphylaxis
  • Tolerance

Cite this

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Attenuated methacholine airway response following repeat testing in a murine model of allergic airways disease. / McKenzie, Ross; Royce, Simon G.; Burton, Matthew D.; Tang, Mimi L. K.

In: Experimental Lung Research, Vol. 34, No. 5, 06.2008, p. 277-286.

Research output: Contribution to journalArticleResearchpeer-review

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