Attenuated 5-HT2 receptor-mediated responses in hindquarters of diabetic rats

Gail M. James; Wayne C. Hodgson

doi:10.1016/0014-2999(95)00524-2

Attenuated 5-HT₂ receptor-mediated responses in hindquarters of diabetic rats

Gail M. James, Wayne C. Hodgson

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

Vasoconstrictor responses to 5-hydroxytryptamine (5-HT), α-methyl-5-HT, endothelin-1, arachidonic acid and the throm{ballot box}ane A₂-mimetic U46619 ((15S)-hydroxy-11α,9α-(cpoxymethano)prosta-5Z,13E-dienoic acid) were obtained in blood-perfused hindquarters of 6-week streptozotocin-diabetic rats. When compared to responses obtained in hindquarters of control rats. responses to 5-HT, α-methyl-5-HT, and arachidonic acid were attenuated in hindquarters of diabetic rats. However, responses to endothelin-I or U46619 were not significantly different between controls and diabetics. These results suggest that 5-HT₂, but not endothelin ET_A receptor-mediated responses are reduced in hindquarters of diabetic rats. The results utilising arachidonic acid and U46619 suggest that there may also be a defect in the cyclo-oxygenase cascade during diabetes.

Original language	English
Pages (from-to)	109-115
Number of pages	7
Journal	European Journal of Pharmacology
Volume	294
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(95)00524-2
Publication status	Published - 27 Dec 1995

Keywords

5-HT (5-hydroxytryptamine, serotonin)
Arachidonic acid
Diabetes
Endothelin
Hindquarters
Throm{ballot box}ane

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0014-2999(95)00524-2

Cite this

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title = "Attenuated 5-HT2 receptor-mediated responses in hindquarters of diabetic rats",

abstract = "Vasoconstrictor responses to 5-hydroxytryptamine (5-HT), α-methyl-5-HT, endothelin-1, arachidonic acid and the throm{ballot box}ane A2-mimetic U46619 ((15S)-hydroxy-11α,9α-(cpoxymethano)prosta-5Z,13E-dienoic acid) were obtained in blood-perfused hindquarters of 6-week streptozotocin-diabetic rats. When compared to responses obtained in hindquarters of control rats. responses to 5-HT, α-methyl-5-HT, and arachidonic acid were attenuated in hindquarters of diabetic rats. However, responses to endothelin-I or U46619 were not significantly different between controls and diabetics. These results suggest that 5-HT2, but not endothelin ETA receptor-mediated responses are reduced in hindquarters of diabetic rats. The results utilising arachidonic acid and U46619 suggest that there may also be a defect in the cyclo-oxygenase cascade during diabetes.",

keywords = "5-HT (5-hydroxytryptamine, serotonin), Arachidonic acid, Diabetes, Endothelin, Hindquarters, Throm{ballot box}ane",

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T1 - Attenuated 5-HT2 receptor-mediated responses in hindquarters of diabetic rats

AU - James, Gail M.

AU - Hodgson, Wayne C.

PY - 1995/12/27

Y1 - 1995/12/27

N2 - Vasoconstrictor responses to 5-hydroxytryptamine (5-HT), α-methyl-5-HT, endothelin-1, arachidonic acid and the throm{ballot box}ane A2-mimetic U46619 ((15S)-hydroxy-11α,9α-(cpoxymethano)prosta-5Z,13E-dienoic acid) were obtained in blood-perfused hindquarters of 6-week streptozotocin-diabetic rats. When compared to responses obtained in hindquarters of control rats. responses to 5-HT, α-methyl-5-HT, and arachidonic acid were attenuated in hindquarters of diabetic rats. However, responses to endothelin-I or U46619 were not significantly different between controls and diabetics. These results suggest that 5-HT2, but not endothelin ETA receptor-mediated responses are reduced in hindquarters of diabetic rats. The results utilising arachidonic acid and U46619 suggest that there may also be a defect in the cyclo-oxygenase cascade during diabetes.

AB - Vasoconstrictor responses to 5-hydroxytryptamine (5-HT), α-methyl-5-HT, endothelin-1, arachidonic acid and the throm{ballot box}ane A2-mimetic U46619 ((15S)-hydroxy-11α,9α-(cpoxymethano)prosta-5Z,13E-dienoic acid) were obtained in blood-perfused hindquarters of 6-week streptozotocin-diabetic rats. When compared to responses obtained in hindquarters of control rats. responses to 5-HT, α-methyl-5-HT, and arachidonic acid were attenuated in hindquarters of diabetic rats. However, responses to endothelin-I or U46619 were not significantly different between controls and diabetics. These results suggest that 5-HT2, but not endothelin ETA receptor-mediated responses are reduced in hindquarters of diabetic rats. The results utilising arachidonic acid and U46619 suggest that there may also be a defect in the cyclo-oxygenase cascade during diabetes.

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KW - Arachidonic acid

KW - Diabetes

KW - Endothelin

KW - Hindquarters

KW - Throm{ballot box}ane

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