Attention, inhibition, and proximity to clinical onset in preclinical mutation carriers for Huntington's disease

Maree Ann Farrow, Andrew Churchyard, Phyllis Chua, John Lockyer Bradshaw, Edmond Chiu, Nellie Georgiou-Karistianis

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20 Citations (Scopus)

Abstract

Research in preclinical mutation carriers for Huntington s disease (HD) aims to find measures sensitive to preclinical decline. This study investigated attentional abilities in mutation carriers and noncarriers. Mutation carriers demonstrated a normal attentional blink during rapid serial visual presentation, normal covert visual orienting, and normal directing of attention to tactile stimuli. However, they were more likely than noncarriers to make anticipatory responses before target presentation. Additionally, those closer to estimated onset of HD demonstrated larger inhibition of return effects. The findings suggest potential changes in cognitive inhibition of unwanted responses, and in automatic inhibition of visual orienting, in preclinical HD.
Original languageEnglish
Pages (from-to)235 - 246
Number of pages12
JournalJournal of Clinical and Experimental Neuropsychology
Volume29
Issue number3
Publication statusPublished - 2007

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