Attempted enantioselective synthesis of terbutaline. unexpected partial racemization during lithium aluminum hydride reduction of a secondary amide

Andrew C. Donohue; W. Roy Jackson

doi:10.1071/CH9951741

Attempted enantioselective synthesis of terbutaline. unexpected partial racemization during lithium aluminum hydride reduction of a secondary amide

Andrew C. Donohue, W. Roy Jackson

Research output: Contribution to journal › Article › Research › peer-review

8 Citations (Scopus)

Abstract

Syntheses leading to compounds related to the bronchodilator (–)- terbutaline via optically active cyanohydrins suffered unexpected partial racemization during lithium aluminium hydride reduction of key amide intermediates.

Original language	English
Pages (from-to)	1741-1746
Number of pages	6
Journal	Australian Journal of Chemistry
Volume	48
Issue number	10
DOIs	https://doi.org/10.1071/CH9951741
Publication status	Published - 1 Jan 1995

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title = "Attempted enantioselective synthesis of terbutaline. unexpected partial racemization during lithium aluminum hydride reduction of a secondary amide",

abstract = "Syntheses leading to compounds related to the bronchodilator (–)- terbutaline via optically active cyanohydrins suffered unexpected partial racemization during lithium aluminium hydride reduction of key amide intermediates.",

author = "Donohue, {Andrew C.} and Jackson, {W. Roy}",

year = "1995",

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N2 - Syntheses leading to compounds related to the bronchodilator (–)- terbutaline via optically active cyanohydrins suffered unexpected partial racemization during lithium aluminium hydride reduction of key amide intermediates.

AB - Syntheses leading to compounds related to the bronchodilator (–)- terbutaline via optically active cyanohydrins suffered unexpected partial racemization during lithium aluminium hydride reduction of key amide intermediates.

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JO - Australian Journal of Chemistry

JF - Australian Journal of Chemistry

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ER -

Attempted enantioselective synthesis of terbutaline. unexpected partial racemization during lithium aluminum hydride reduction of a secondary amide

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