Atrial electrical and structural abnormalities in an ovine model of chronic blood pressure elevation after prenatal corticosteroid exposure: Implications for development of atrial fibrillation

Peter Kistler, Prashanthan Sanders, Miodrag Dodic, Steven Spence, Chrishan Samuel, Chongxin Zhao, Jennifer Charles, Glenn Edwards, Johnathon Kalman

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Abstract

AIMS: Elevated blood pressure (EBP) is the most prevalent and potentially modifiable risk factor for AF, yet little is known of its atrial effects. We aimed to characterize the atrial electrical and structural changes in a chronic ovine model of EBP after prenatal corticosteroid exposure. METHODS AND RESULTS: Twelve sheep with chronically EBP (mean arterial pressure 94+/-3 mmHg) and six controls (71+/-4 mmHg, P
Original languageEnglish
Pages (from-to)3045 - 3056
Number of pages12
JournalEuropean Heart Journal
Volume27
Issue number24
DOIs
Publication statusPublished - 2006
Externally publishedYes

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