Atorvastatin enhances humoral immune responses but does not alter renal injury in experimental crescentic glomerulonephritis

Richard Kwok Sing Phoon, Arthur Richard Kitching, Lynelle Karyn Jones, Stephen Roger Holdsworth

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Abstract

Atorvastatin enhances humoral immune responses but does not alter renal injury in experimental crescentic glomerulonephritis. Statins are widely used for their cholesterol-lowering effects and for prevention of cardiovascular disease. Evidence indicates that these drugs also have immunomodulatory and other non-lipid lowering effects, with studies suggesting benefit in some animal models of immune (particularly T helper (Th)1)-mediated inflammatory disease and their corresponding human disease counterparts. We sought to evaluate the immunomodulatory effects and therapeutic potential of atorvastatin in experimental crescentic glomerulonephritis, a Th1-predominant animal model of glomerulonephritis.
Original languageEnglish
Pages (from-to)650 - 657
Number of pages8
JournalNephrology
Volume14
Issue number7
DOIs
Publication statusPublished - 2009

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