Atorvastatin enhances humoral immune responses but does not alter renal injury in experimental crescentic glomerulonephritis. Statins are widely used for their cholesterol-lowering effects and for prevention of cardiovascular disease. Evidence indicates that these drugs also have immunomodulatory and other non-lipid lowering effects, with studies suggesting benefit in some animal models of immune (particularly T helper (Th)1)-mediated inflammatory disease and their corresponding human disease counterparts. We sought to evaluate the immunomodulatory effects and therapeutic potential of atorvastatin in experimental crescentic glomerulonephritis, a Th1-predominant animal model of glomerulonephritis.
Phoon, R. K. S., Kitching, A. R., Jones, L. K., & Holdsworth, S. R. (2009). Atorvastatin enhances humoral immune responses but does not alter renal injury in experimental crescentic glomerulonephritis. Nephrology, 14(7), 650 - 657. https://doi.org/10.1111/j.1440-1797.2009.01141.x