Atomic force microscopy: From red blood cells to immunohaematology

Natasha Yeow; Richard Francis Tabor; Gil Garnier

doi:10.1016/j.cis.2017.05.011

Atomic force microscopy: From red blood cells to immunohaematology

Natasha Yeow, Richard Francis Tabor, Gil Garnier

Research output: Contribution to journal › Article › Research › peer-review

37 Citations (Scopus)

Abstract

Atomic force microscopy (AFM) offers complementary imaging modes that can provide morphological and structural details of red blood cells (RBCs), and characterize interactions between specific biomolecules and RBC surface antigen. This review describes the applications of AFM in determining RBC health by the observation of cell morphology, elasticity and surface roughness. Measurement of interaction forces between plasma proteins and antibodies against RBC surface antigen using the AFM also brought new information to the immunohaematology field. With constant improvisation of the AFM in resolution and imaging time, the reaction of RBC to changes in the physico-chemistry of its environment and the presence of RBC surface antigen specific-biomolecules is achievable.

Original language	English
Pages (from-to)	149-162
Number of pages	14
Journal	Advances in Colloid and Interface Science
Volume	249
DOIs	https://doi.org/10.1016/j.cis.2017.05.011
Publication status	Published - 1 Nov 2017

Keywords

AFM
Atomic force microscopy
Force spectroscopy
Immunohaematology
Red blood cell

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title = "Atomic force microscopy: From red blood cells to immunohaematology",

abstract = "Atomic force microscopy (AFM) offers complementary imaging modes that can provide morphological and structural details of red blood cells (RBCs), and characterize interactions between specific biomolecules and RBC surface antigen. This review describes the applications of AFM in determining RBC health by the observation of cell morphology, elasticity and surface roughness. Measurement of interaction forces between plasma proteins and antibodies against RBC surface antigen using the AFM also brought new information to the immunohaematology field. With constant improvisation of the AFM in resolution and imaging time, the reaction of RBC to changes in the physico-chemistry of its environment and the presence of RBC surface antigen specific-biomolecules is achievable.",

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AU - Garnier, Gil

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AB - Atomic force microscopy (AFM) offers complementary imaging modes that can provide morphological and structural details of red blood cells (RBCs), and characterize interactions between specific biomolecules and RBC surface antigen. This review describes the applications of AFM in determining RBC health by the observation of cell morphology, elasticity and surface roughness. Measurement of interaction forces between plasma proteins and antibodies against RBC surface antigen using the AFM also brought new information to the immunohaematology field. With constant improvisation of the AFM in resolution and imaging time, the reaction of RBC to changes in the physico-chemistry of its environment and the presence of RBC surface antigen specific-biomolecules is achievable.

KW - AFM

KW - Atomic force microscopy

KW - Force spectroscopy

KW - Immunohaematology

KW - Red blood cell

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JO - Advances in Colloid and Interface Science

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Atomic force microscopy: From red blood cells to immunohaematology

Abstract

Keywords

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