Abstract
Atomic force microscopy (AFM) offers complementary imaging modes that can provide morphological and structural details of red blood cells (RBCs), and characterize interactions between specific biomolecules and RBC surface antigen. This review describes the applications of AFM in determining RBC health by the observation of cell morphology, elasticity and surface roughness. Measurement of interaction forces between plasma proteins and antibodies against RBC surface antigen using the AFM also brought new information to the immunohaematology field. With constant improvisation of the AFM in resolution and imaging time, the reaction of RBC to changes in the physico-chemistry of its environment and the presence of RBC surface antigen specific-biomolecules is achievable.
| Original language | English |
|---|---|
| Pages (from-to) | 149-162 |
| Number of pages | 14 |
| Journal | Advances in Colloid and Interface Science |
| Volume | 249 |
| DOIs | |
| Publication status | Published - 1 Nov 2017 |
Keywords
- AFM
- Atomic force microscopy
- Force spectroscopy
- Immunohaematology
- Red blood cell
Cite this
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Atomic force microscopy : From red blood cells to immunohaematology. / Yeow, Natasha; Tabor, Richard Francis; Garnier, Gil.
In: Advances in Colloid and Interface Science, Vol. 249, 01.11.2017, p. 149-162.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Atomic force microscopy
T2 - From red blood cells to immunohaematology
AU - Yeow, Natasha
AU - Tabor, Richard Francis
AU - Garnier, Gil
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Atomic force microscopy (AFM) offers complementary imaging modes that can provide morphological and structural details of red blood cells (RBCs), and characterize interactions between specific biomolecules and RBC surface antigen. This review describes the applications of AFM in determining RBC health by the observation of cell morphology, elasticity and surface roughness. Measurement of interaction forces between plasma proteins and antibodies against RBC surface antigen using the AFM also brought new information to the immunohaematology field. With constant improvisation of the AFM in resolution and imaging time, the reaction of RBC to changes in the physico-chemistry of its environment and the presence of RBC surface antigen specific-biomolecules is achievable.
AB - Atomic force microscopy (AFM) offers complementary imaging modes that can provide morphological and structural details of red blood cells (RBCs), and characterize interactions between specific biomolecules and RBC surface antigen. This review describes the applications of AFM in determining RBC health by the observation of cell morphology, elasticity and surface roughness. Measurement of interaction forces between plasma proteins and antibodies against RBC surface antigen using the AFM also brought new information to the immunohaematology field. With constant improvisation of the AFM in resolution and imaging time, the reaction of RBC to changes in the physico-chemistry of its environment and the presence of RBC surface antigen specific-biomolecules is achievable.
KW - AFM
KW - Atomic force microscopy
KW - Force spectroscopy
KW - Immunohaematology
KW - Red blood cell
UR - http://www.scopus.com/inward/record.url?scp=85019225809&partnerID=8YFLogxK
U2 - 10.1016/j.cis.2017.05.011
DO - 10.1016/j.cis.2017.05.011
M3 - Article
AN - SCOPUS:85019225809
VL - 249
SP - 149
EP - 162
JO - Advances in Colloid and Interface Science
JF - Advances in Colloid and Interface Science
SN - 0001-8686
ER -