Atom-economical construction of a rare 6,7-dihydropyrido[3′,2′: 4,5]imidazo[1,2- d ][1,4]benzodiazepine scaffold

Prashant Mujumdar; Mikhail Korsakov; Mikhail Dorogov; Mikhail Krasavin

doi:10.1055/s-0034-1378558

Atom-economical construction of a rare 6,7-dihydropyrido[3′,2′: 4,5]imidazo[1,2- d ][1,4]benzodiazepine scaffold

Prashant Mujumdar
, Mikhail Korsakov
, Mikhail Dorogov
, Mikhail Krasavin

Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)

Abstract

We have developed a route towards novel 6,7-dihydropyrido[3′,2′:4,5]imidazo[1,2-d][1,4]benzodiazepines, in five straightforward steps from commercially available 2-bromobenzaldehydes and 3-(2-aminoethyl)imidazo[4,5-b]pyridines we have described previously, with full control over the three elements of diversity. The route appears to be suitable for systematic exploration of structure-activity relationships around this medicinally relevant tetracyclic scaffold.

Original language	English
Article number	st-2014-d0454-l
Pages (from-to)	2323-2326
Number of pages	4
Journal	Synlett
Volume	25
Issue number	16
DOIs	https://doi.org/10.1055/s-0034-1378558
Publication status	Published - 1 Oct 2014
Externally published	Yes

Keywords

Bechamp reduction
Buchwald arylation
scaffold-oriented synthesis

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AU - Mujumdar, Prashant

AU - Korsakov, Mikhail

AU - Dorogov, Mikhail

AU - Krasavin, Mikhail

PY - 2014/10/1

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AB - We have developed a route towards novel 6,7-dihydropyrido[3′,2′:4,5]imidazo[1,2-d][1,4]benzodiazepines, in five straightforward steps from commercially available 2-bromobenzaldehydes and 3-(2-aminoethyl)imidazo[4,5-b]pyridines we have described previously, with full control over the three elements of diversity. The route appears to be suitable for systematic exploration of structure-activity relationships around this medicinally relevant tetracyclic scaffold.

KW - Bechamp reduction

KW - Buchwald arylation

KW - scaffold-oriented synthesis

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JO - Synlett

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ER -

Atom-economical construction of a rare 6,7-dihydropyrido[3′,2′: 4,5]imidazo[1,2- d ][1,4]benzodiazepine scaffold

Abstract

Keywords

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