Atom-economical construction of a rare 6,7-dihydropyrido[3′,2′: 4,5]imidazo[1,2- d ][1,4]benzodiazepine scaffold

Prashant Mujumdar, Mikhail Korsakov, Mikhail Dorogov, Mikhail Krasavin

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)


We have developed a route towards novel 6,7-dihydropyrido[3′,2′:4,5]imidazo[1,2-d][1,4]benzodiazepines, in five straightforward steps from commercially available 2-bromobenzaldehydes and 3-(2-aminoethyl)imidazo[4,5-b]pyridines we have described previously, with full control over the three elements of diversity. The route appears to be suitable for systematic exploration of structure-activity relationships around this medicinally relevant tetracyclic scaffold.

Original languageEnglish
Article numberst-2014-d0454-l
Pages (from-to)2323-2326
Number of pages4
Issue number16
Publication statusPublished - 1 Oct 2014
Externally publishedYes


  • Bechamp reduction
  • Buchwald arylation
  • scaffold-oriented synthesis

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