Abstract
THE NEED FOR AN ATLAS OF ZEBRAFISH DEVELOPMENT
Over the past two decades zebrafish have been established as a genetically tractable model system to investigate
many different aspects of vertebrate development. The strengths of this model system stem from a unique combination
of embryological manipulability and the optical clarity of the early embryo and larvae, which allows, by simple
optical inspection, the visualization of cell biological events within an in vivo context. This is further enhanced by
the ability to apply invertebrate-style forward genetics to questions of vertebrate development. While the credentials
of the system as a developmental model have long been recognized, it is the application of the zebrafish to a different
aspect of biology that has generated a surge in popularity and greatly increased zebrafish laboratory use. Many
investigators have now turned to directly modeling human disease states in zebrafish, realizing that many of the
same strengths that made it a compelling model for the study of development also allow it to complement existing
mammalian disease models (Lieschke and Currie 2007).
Original language | English |
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Place of Publication | UK |
Publisher | Academic Press |
Number of pages | 232 |
Edition | 1st |
ISBN (Print) | 9780123740168 |
Publication status | Published - 2012 |