Atherosclerotic Plaque Rupture: Identifying the Straw That Breaks the Camel?s Back

Yung Chih Chen, Alex L. Huang, Tin S. Kyaw, Alex Bobik, Karlheinz Peter

Research output: Contribution to journalArticleOtherpeer-review

20 Citations (Scopus)

Abstract

It is easy to see the breaking of the camel's back, as it is typically an obvious, final, and dramatic scene that catches everyone by surprise. Yet it is difficult to see the straw itself and to understand all the strain that silently builds up and contributes to the final event. Similarly, the rupture of unstable atherosclerotic plaques is a complex process ultimately representing a maladaptive response to hemodynamic conditions, lipid accumulation, arterial injury, necrosis, and inflammation. Growing understanding of the many facets of this pathological process offers multiple opportunities for early detection of unstable plaques with biomarkers and novel molecular imaging technologies, and hopefully will ultimately lead to the development of utterly needed plaque-stabilizing drugs.

Original languageEnglish
Pages (from-to)e63-e72
JournalArteriosclerosis, Thrombosis and Vascular Biology
Volume36
Issue number8
DOIs
Publication statusPublished - 1 Aug 2016

Keywords

  • atherosclerosis
  • atherosclerotic plaque
  • biomarkers
  • C-reactive protein
  • interleukins

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