Atherosclerosis imaging in drug development

Stephen J. Nicholls, Srinivasa Kalidindi, Keon Woong Moon, Steven E. Nissen

Research output: Contribution to journalReview ArticleResearchpeer-review


Increasing use of established medical therapies presents a major challenge for the assessment of experimental antiatherosclerotic agents. The requirement to perform clinical trials with increasing numbers of subjects, followed for longer periods of time, creates a scenario that is largely prohibitive for the development of most new agents. Technologic advances in arterial wall imaging provide the opportunity to evaluate the impact of therapies on the natural history of atherosclerosis. The design and implementation of clinical trials that employ serial imaging of the arterial wall has become increasingly used in the development of new therapies to target atherosclerotic cardiovascular disease.

Original languageEnglish
Pages (from-to)1241-1250
Number of pages10
JournalExpert Opinion on Drug Discovery
Issue number9
Publication statusPublished - 1 Sept 2007
Externally publishedYes


  • Atherosclerosis
  • Drug development
  • Imaging
  • Risk factor

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