Xiao Jun Du, Anthony M. Dart

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review


It has now become clear that the physiological and pharmacological behaviour of vascular smooth muscle, particularly in the coronary circulation, is abnormal throughout the evolution of atherosclerosis. This chapter reviews these pathophysiological alterations and the consequently modified (or even paradoxical) pharmacological characteristics of coronary vasculature. Clinical and experimental studies on atherosclerotic coronary arteries have demonstrated an abnormal vasoconstriction in response to various pharmacological agents which induce vasodilation in non-atherosclerotic arteries. Intracoronary injection of ACh or 5-HT in man induces a dose-dependent vasoconstrictor response in segments with atherosclerotic damage but the vasodilator response to nitroglycerin is intact.

Original languageEnglish
Title of host publicationThe Pharmacology of Vascular Smooth Muscle
EditorsC. J. Garland, J. A. Angus
Place of PublicationNew York NY USA
PublisherOxford University Press, USA
Number of pages13
ISBN (Electronic)9780191724671
ISBN (Print)9780192623874
Publication statusPublished - 1996
Externally publishedYes


  • Acetylcholine
  • Coronary arteries
  • Coronary circulation
  • Coronary vasculature
  • Vasoconstriction
  • Vasodilation

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