Atherosclerosis

Xiao Jun Du; Anthony M. Dart

doi:10.1093/acprof:oso/9780192623874.003.0014

Atherosclerosis

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

Abstract

It has now become clear that the physiological and pharmacological behaviour of vascular smooth muscle, particularly in the coronary circulation, is abnormal throughout the evolution of atherosclerosis. This chapter reviews these pathophysiological alterations and the consequently modified (or even paradoxical) pharmacological characteristics of coronary vasculature. Clinical and experimental studies on atherosclerotic coronary arteries have demonstrated an abnormal vasoconstriction in response to various pharmacological agents which induce vasodilation in non-atherosclerotic arteries. Intracoronary injection of ACh or 5-HT in man induces a dose-dependent vasoconstrictor response in segments with atherosclerotic damage but the vasodilator response to nitroglycerin is intact.

Original language	English
Title of host publication	The Pharmacology of Vascular Smooth Muscle
Editors	C. J. Garland, J. A. Angus
Place of Publication	New York NY USA
Publisher	Oxford University Press, USA
Pages	328-340
Number of pages	13
ISBN (Electronic)	9780191724671
ISBN (Print)	9780192623874
DOIs	https://doi.org/10.1093/acprof:oso/9780192623874.003.0014
Publication status	Published - 1996
Externally published	Yes

Keywords

Acetylcholine
Coronary arteries
Coronary circulation
Coronary vasculature
Vasoconstriction
Vasodilation

Access to Document

10.1093/acprof:oso/9780192623874.003.0014

Link to publication in Scopus

Cite this

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title = "Atherosclerosis",

abstract = "It has now become clear that the physiological and pharmacological behaviour of vascular smooth muscle, particularly in the coronary circulation, is abnormal throughout the evolution of atherosclerosis. This chapter reviews these pathophysiological alterations and the consequently modified (or even paradoxical) pharmacological characteristics of coronary vasculature. Clinical and experimental studies on atherosclerotic coronary arteries have demonstrated an abnormal vasoconstriction in response to various pharmacological agents which induce vasodilation in non-atherosclerotic arteries. Intracoronary injection of ACh or 5-HT in man induces a dose-dependent vasoconstrictor response in segments with atherosclerotic damage but the vasodilator response to nitroglycerin is intact.",

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author = "Du, {Xiao Jun} and Dart, {Anthony M.}",

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AU - Dart, Anthony M.

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AB - It has now become clear that the physiological and pharmacological behaviour of vascular smooth muscle, particularly in the coronary circulation, is abnormal throughout the evolution of atherosclerosis. This chapter reviews these pathophysiological alterations and the consequently modified (or even paradoxical) pharmacological characteristics of coronary vasculature. Clinical and experimental studies on atherosclerotic coronary arteries have demonstrated an abnormal vasoconstriction in response to various pharmacological agents which induce vasodilation in non-atherosclerotic arteries. Intracoronary injection of ACh or 5-HT in man induces a dose-dependent vasoconstrictor response in segments with atherosclerotic damage but the vasodilator response to nitroglycerin is intact.

KW - Acetylcholine

KW - Coronary arteries

KW - Coronary circulation

KW - Coronary vasculature

KW - Vasoconstriction

KW - Vasodilation

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BT - The Pharmacology of Vascular Smooth Muscle

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