Atherogenic factors and their epigenetic relationships

Ana Z Fernandez, Andrew L. Siebel, Assam El-Osta

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Hypercholesterolemia, homocysteine, oxidative stress, and hyperglycemia have been recognized as the major risk factors for atherogenesis. Their impact on the physiology and biochemistry of vascular cells has been widely demonstrated for the last century. However, the recent discovery of the role of epigenetics in human disease has opened up a new field in the study of atherogenic factors. Thus, epigenetic tags in endothelial, smooth muscle, and immune cells seem to be differentially affected by similar atherogenic stimuli. This paper summarizes some recent works on expression of histone-modifying enzymes and DNA methylation directly linked to the presence of risk factors that could lead to the development or prevention of the atherosclerotic process.

Original languageEnglish
Article number437809
JournalInternational Journal of Vascular Medicine
Volume2010
DOIs
Publication statusPublished - 2010
Externally publishedYes

Cite this

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title = "Atherogenic factors and their epigenetic relationships",
abstract = "Hypercholesterolemia, homocysteine, oxidative stress, and hyperglycemia have been recognized as the major risk factors for atherogenesis. Their impact on the physiology and biochemistry of vascular cells has been widely demonstrated for the last century. However, the recent discovery of the role of epigenetics in human disease has opened up a new field in the study of atherogenic factors. Thus, epigenetic tags in endothelial, smooth muscle, and immune cells seem to be differentially affected by similar atherogenic stimuli. This paper summarizes some recent works on expression of histone-modifying enzymes and DNA methylation directly linked to the presence of risk factors that could lead to the development or prevention of the atherosclerotic process.",
author = "Fernandez, {Ana Z} and Siebel, {Andrew L.} and Assam El-Osta",
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language = "English",
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Atherogenic factors and their epigenetic relationships. / Fernandez, Ana Z; Siebel, Andrew L.; El-Osta, Assam.

In: International Journal of Vascular Medicine, Vol. 2010, 437809, 2010.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Atherogenic factors and their epigenetic relationships

AU - Fernandez, Ana Z

AU - Siebel, Andrew L.

AU - El-Osta, Assam

PY - 2010

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N2 - Hypercholesterolemia, homocysteine, oxidative stress, and hyperglycemia have been recognized as the major risk factors for atherogenesis. Their impact on the physiology and biochemistry of vascular cells has been widely demonstrated for the last century. However, the recent discovery of the role of epigenetics in human disease has opened up a new field in the study of atherogenic factors. Thus, epigenetic tags in endothelial, smooth muscle, and immune cells seem to be differentially affected by similar atherogenic stimuli. This paper summarizes some recent works on expression of histone-modifying enzymes and DNA methylation directly linked to the presence of risk factors that could lead to the development or prevention of the atherosclerotic process.

AB - Hypercholesterolemia, homocysteine, oxidative stress, and hyperglycemia have been recognized as the major risk factors for atherogenesis. Their impact on the physiology and biochemistry of vascular cells has been widely demonstrated for the last century. However, the recent discovery of the role of epigenetics in human disease has opened up a new field in the study of atherogenic factors. Thus, epigenetic tags in endothelial, smooth muscle, and immune cells seem to be differentially affected by similar atherogenic stimuli. This paper summarizes some recent works on expression of histone-modifying enzymes and DNA methylation directly linked to the presence of risk factors that could lead to the development or prevention of the atherosclerotic process.

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U2 - 10.1155/2010/437809

DO - 10.1155/2010/437809

M3 - Review Article

VL - 2010

JO - International Journal of Vascular Medicine

JF - International Journal of Vascular Medicine

SN - 2090-2824

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ER -