TY - JOUR
T1 - ATF3 transcription factor and its emerging roles in immunity and cancer
AU - Thompson, Matthew R
AU - Xu, Dakang
AU - Williams, Bryan Raymond George
PY - 2009
Y1 - 2009
N2 - Activating transcription factor 3 (ATF3) is a member of the ATF/cyclic AMP response element-binding (ATF/CREB) family of transcription factors. It is an adaptive-response gene that participates in cellular processes to adapt to extra- and/or intracellular changes, where it transduces signals from various receptors to activate or repress gene expression. Advances made in understanding the immunobiology of Toll-like receptors have recently generated new momentum for the study of ATF3 in immunity. Moreover, the role of ATF3 in the regulation of the cell cycle and apoptosis has important implications for understanding susceptibility to and progression of several cancers.
AB - Activating transcription factor 3 (ATF3) is a member of the ATF/cyclic AMP response element-binding (ATF/CREB) family of transcription factors. It is an adaptive-response gene that participates in cellular processes to adapt to extra- and/or intracellular changes, where it transduces signals from various receptors to activate or repress gene expression. Advances made in understanding the immunobiology of Toll-like receptors have recently generated new momentum for the study of ATF3 in immunity. Moreover, the role of ATF3 in the regulation of the cell cycle and apoptosis has important implications for understanding susceptibility to and progression of several cancers.
UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19705082
U2 - 10.1007/s00109-009-0520-x
DO - 10.1007/s00109-009-0520-x
M3 - Article
SN - 0946-2716
VL - 87
SP - 1053
EP - 1060
JO - Journal of Molecular Medicine
JF - Journal of Molecular Medicine
IS - 11
ER -
