AT4 receptor is insulin-regulated membrane aminopeptidase: Potential mechanisms of memory enhancement

Anthony L. Albiston, Tomris Mustafa, Sharon G. McDowall, Frederick A O Mendelsohn, Joohyung Lee, Siew Yeen Chai

Research output: Contribution to journalReview ArticleResearchpeer-review

80 Citations (Scopus)

Abstract

Although angiotensin IV (Ang IV) was thought initially to be an inactive product of Ang II degradation, it was subsequently shown that the hexapeptide markedly enhances learning and memory in normal rodents and reverses the memory deficits seen in animal models of amnesia. These central nervous system effects of Ang IV are mediated by binding to a specific site, known as the AT4 receptor, which is found in appreciable levels throughout the brain and is concentrated particularly in regions involved in cognition. This field of research was redefined by the identification of the AT4 receptor as the transmembrane enzyme, insulin-regulated membrane aminopeptidase (IRAP). Here, we explore the potential mechanisms by which Ang IV binding to IRAP leads to the facilitation of learning and memory.

Original languageEnglish
Pages (from-to)72-77
Number of pages6
JournalTrends in Endocrinology and Metabolism
Volume14
Issue number2
DOIs
Publication statusPublished - Mar 2003
Externally publishedYes

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