AT2R, vascular effects, and blood pressure

Dhaniel Dias Baraldi, Emma S Jones, Lucinda M Hilliard, Mark P Del Borgo, Tracey A Gaspari, Claudia Ann McCarthy, Antony Vinh, Iresha Weungoda, Marie-Isabel Isabel Aguilar, Katherine M Denton, Robert E Widdop

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review


This chapter summarizes the predominantly vasodilator effects of AT2R in the vasculature based on both in vitro and in vivo preclinical studies, before describing the effects of chronic AT2R stimulation on blood pressure. Generally, AT2R agonists are not considered to be antihypertensive in preclinical models despite the fact that vascular AT2Rs are functionally active in preclinical studies and in a number of acute human studies (ex vivo and in vivo). Possible mechanisms are explored to explain the apparent lack of effect of AT2R on blood pressure in chronic pharmacological studies that would not have been predicted from the large body of evidence documenting AT2R-mediated vasodilator function.
Original languageEnglish
Title of host publicationThe Protective Arm of the Renin-Angiotensin System
Subtitle of host publicationFunctional Aspects and Therapeutic Implications
EditorsThomas Unger, Ulrike M. Steckelings, Robson A. S. dos Santos
Place of PublicationLondon UK
Pages49 - 55
Number of pages7
ISBN (Print)9780128013649
Publication statusPublished - 2015

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