AT2R, vascular effects, and blood pressure

Dhaniel Dias Baraldi; Emma S Jones; Lucinda M Hilliard; Mark P Del Borgo; Tracey A Gaspari; Claudia Ann McCarthy; Antony Vinh; Iresha Weungoda; Marie-Isabel Isabel Aguilar; Katherine M Denton; Robert E Widdop

doi:10.1016/B978-0-12-801364-9.00007-9

AT2R, vascular effects, and blood pressure

Dhaniel Dias Baraldi, Emma S Jones, Lucinda M Hilliard, Mark P Del Borgo, Tracey A Gaspari, Claudia Ann McCarthy, Antony Vinh, Iresha Weungoda, Marie-Isabel Isabel Aguilar, Katherine M Denton, Robert E Widdop

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

Abstract

This chapter summarizes the predominantly vasodilator effects of AT2R in the vasculature based on both in vitro and in vivo preclinical studies, before describing the effects of chronic AT2R stimulation on blood pressure. Generally, AT2R agonists are not considered to be antihypertensive in preclinical models despite the fact that vascular AT2Rs are functionally active in preclinical studies and in a number of acute human studies (ex vivo and in vivo). Possible mechanisms are explored to explain the apparent lack of effect of AT2R on blood pressure in chronic pharmacological studies that would not have been predicted from the large body of evidence documenting AT2R-mediated vasodilator function.

Original language	English
Title of host publication	The Protective Arm of the Renin-Angiotensin System
Subtitle of host publication	Functional Aspects and Therapeutic Implications
Editors	Thomas Unger, Ulrike M. Steckelings, Robson A. S. dos Santos
Place of Publication	London UK
Publisher	Elsevier
Pages	49 - 55
Number of pages	7
Edition	1st
ISBN (Print)	9780128013649
DOIs	https://doi.org/10.1016/B978-0-12-801364-9.00007-9
Publication status	Published - 2015

Access to Document

10.1016/B978-0-12-801364-9.00007-9

Cite this

Dias Baraldi, D., Jones, E. S., Hilliard, L. M., Del Borgo, M. P., Gaspari, T. A., McCarthy, C. A., Vinh, A., Weungoda, I., Aguilar, M.-I. I., Denton, K. M., & Widdop, R. E. (2015). AT2R, vascular effects, and blood pressure. In T. Unger, U. M. Steckelings, & R. A. S. dos Santos (Eds.), The Protective Arm of the Renin-Angiotensin System: Functional Aspects and Therapeutic Implications (1st ed., pp. 49 - 55). Elsevier. https://doi.org/10.1016/B978-0-12-801364-9.00007-9

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abstract = "This chapter summarizes the predominantly vasodilator effects of AT2R in the vasculature based on both in vitro and in vivo preclinical studies, before describing the effects of chronic AT2R stimulation on blood pressure. Generally, AT2R agonists are not considered to be antihypertensive in preclinical models despite the fact that vascular AT2Rs are functionally active in preclinical studies and in a number of acute human studies (ex vivo and in vivo). Possible mechanisms are explored to explain the apparent lack of effect of AT2R on blood pressure in chronic pharmacological studies that would not have been predicted from the large body of evidence documenting AT2R-mediated vasodilator function.",

author = "{Dias Baraldi}, Dhaniel and Jones, {Emma S} and Hilliard, {Lucinda M} and {Del Borgo}, {Mark P} and Gaspari, {Tracey A} and McCarthy, {Claudia Ann} and Antony Vinh and Iresha Weungoda and Aguilar, {Marie-Isabel Isabel} and Denton, {Katherine M} and Widdop, {Robert E}",

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Dias Baraldi, D, Jones, ES, Hilliard, LM , Del Borgo, MP , Gaspari, TA, McCarthy, CA, Vinh, A, Weungoda, I, Aguilar, M-II , Denton, KM & Widdop, RE 2015, AT2R, vascular effects, and blood pressure. in T Unger, UM Steckelings & RAS dos Santos (eds), The Protective Arm of the Renin-Angiotensin System: Functional Aspects and Therapeutic Implications. 1st edn, Elsevier, London UK, pp. 49 - 55. https://doi.org/10.1016/B978-0-12-801364-9.00007-9

AT2R, vascular effects, and blood pressure. / Dias Baraldi, Dhaniel; Jones, Emma S; Hilliard, Lucinda M et al.
The Protective Arm of the Renin-Angiotensin System: Functional Aspects and Therapeutic Implications. ed. / Thomas Unger; Ulrike M. Steckelings; Robson A. S. dos Santos. 1st. ed. London UK: Elsevier, 2015. p. 49 - 55.

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

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T1 - AT2R, vascular effects, and blood pressure

AU - Dias Baraldi, Dhaniel

AU - Jones, Emma S

AU - Hilliard, Lucinda M

AU - Del Borgo, Mark P

AU - Gaspari, Tracey A

AU - McCarthy, Claudia Ann

AU - Vinh, Antony

AU - Weungoda, Iresha

AU - Aguilar, Marie-Isabel Isabel

AU - Denton, Katherine M

AU - Widdop, Robert E

PY - 2015

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AB - This chapter summarizes the predominantly vasodilator effects of AT2R in the vasculature based on both in vitro and in vivo preclinical studies, before describing the effects of chronic AT2R stimulation on blood pressure. Generally, AT2R agonists are not considered to be antihypertensive in preclinical models despite the fact that vascular AT2Rs are functionally active in preclinical studies and in a number of acute human studies (ex vivo and in vivo). Possible mechanisms are explored to explain the apparent lack of effect of AT2R on blood pressure in chronic pharmacological studies that would not have been predicted from the large body of evidence documenting AT2R-mediated vasodilator function.

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BT - The Protective Arm of the Renin-Angiotensin System

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