Asymmetric syntheses of (+)-diltiazem hydrochloride

Keith G. Watson, Yik M. Fung, Matthew Gredley, Graham J. Bird, W. Roy Jackson, Helen Gountzos, Barry R. Matthews

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Abstract

Efficient enantioselective syntheses of the important cardiac drug (+)-cis-(2S,3S)-diltiazem from (E)-methyl 4-methoxyphenylpropenoate via either the (2R,3S)- or (2S,3R)-enantiomers of threo-methyl 3-(4-methoxyphenyl)-2,3- dihydroxypropanoate are described.

Original languageEnglish
Pages (from-to)1018-1019
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number15
DOIs
Publication statusPublished - 1 Dec 1990

Cite this

Watson, K. G., Fung, Y. M., Gredley, M., Bird, G. J., Jackson, W. R., Gountzos, H., & Matthews, B. R. (1990). Asymmetric syntheses of (+)-diltiazem hydrochloride. Journal of the Chemical Society, Chemical Communications, (15), 1018-1019. https://doi.org/10.1039/C39900001018