Asymmetric syntheses of (+)-diltiazem hydrochloride

Keith G. Watson; Yik M. Fung; Matthew Gredley; Graham J. Bird; W. Roy Jackson; Helen Gountzos; Barry R. Matthews

doi:10.1039/C39900001018

Asymmetric syntheses of (+)-diltiazem hydrochloride

Keith G. Watson, Yik M. Fung, Matthew Gredley, Graham J. Bird, W. Roy Jackson, Helen Gountzos, Barry R. Matthews

School of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

91 Citations (Scopus)

Abstract

Efficient enantioselective syntheses of the important cardiac drug (+)-cis-(2S,3S)-diltiazem from (E)-methyl 4-methoxyphenylpropenoate via either the (2R,3S)- or (2S,3R)-enantiomers of threo-methyl 3-(4-methoxyphenyl)-2,3- dihydroxypropanoate are described.

Original language	English
Pages (from-to)	1018-1019
Number of pages	2
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	15
DOIs	https://doi.org/10.1039/C39900001018
Publication status	Published - 1 Dec 1990

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abstract = "Efficient enantioselective syntheses of the important cardiac drug (+)-cis-(2S,3S)-diltiazem from (E)-methyl 4-methoxyphenylpropenoate via either the (2R,3S)- or (2S,3R)-enantiomers of threo-methyl 3-(4-methoxyphenyl)-2,3- dihydroxypropanoate are described.",

author = "Watson, {Keith G.} and Fung, {Yik M.} and Matthew Gredley and Bird, {Graham J.} and Jackson, {W. Roy} and Helen Gountzos and Matthews, {Barry R.}",

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T1 - Asymmetric syntheses of (+)-diltiazem hydrochloride

AU - Watson, Keith G.

AU - Fung, Yik M.

AU - Gredley, Matthew

AU - Bird, Graham J.

AU - Jackson, W. Roy

AU - Gountzos, Helen

AU - Matthews, Barry R.

PY - 1990/12/1

Y1 - 1990/12/1

N2 - Efficient enantioselective syntheses of the important cardiac drug (+)-cis-(2S,3S)-diltiazem from (E)-methyl 4-methoxyphenylpropenoate via either the (2R,3S)- or (2S,3R)-enantiomers of threo-methyl 3-(4-methoxyphenyl)-2,3- dihydroxypropanoate are described.

AB - Efficient enantioselective syntheses of the important cardiac drug (+)-cis-(2S,3S)-diltiazem from (E)-methyl 4-methoxyphenylpropenoate via either the (2R,3S)- or (2S,3R)-enantiomers of threo-methyl 3-(4-methoxyphenyl)-2,3- dihydroxypropanoate are described.

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DO - 10.1039/C39900001018

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JO - Journal of the Chemical Society, Chemical Communications

JF - Journal of the Chemical Society, Chemical Communications

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Asymmetric syntheses of (+)-diltiazem hydrochloride

Abstract

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