Asymmetric syntheses of (+)-diltiazem hydrochloride

Keith G. Watson; Yik M. Fung; Matthew Gredley; Graham J. Bird; W. Roy Jackson; Helen Gountzos; Barry R. Matthews

doi:10.1039/C39900001018

Asymmetric syntheses of (+)-diltiazem hydrochloride

Keith G. Watson, Yik M. Fung, Matthew Gredley, Graham J. Bird, W. Roy Jackson, Helen Gountzos, Barry R. Matthews

School of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

88 Citations (Scopus)

Abstract

Efficient enantioselective syntheses of the important cardiac drug (+)-cis-(2S,3S)-diltiazem from (E)-methyl 4-methoxyphenylpropenoate via either the (2R,3S)- or (2S,3R)-enantiomers of threo-methyl 3-(4-methoxyphenyl)-2,3- dihydroxypropanoate are described.

Original language	English
Pages (from-to)	1018-1019
Number of pages	2
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	15
DOIs	https://doi.org/10.1039/C39900001018
Publication status	Published - 1 Dec 1990

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10.1039/C39900001018

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Cite this

Watson, K. G., Fung, Y. M., Gredley, M., Bird, G. J., Jackson, W. R., Gountzos, H., & Matthews, B. R. (1990). Asymmetric syntheses of (+)-diltiazem hydrochloride. Journal of the Chemical Society, Chemical Communications, (15), 1018-1019. https://doi.org/10.1039/C39900001018

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AU - Fung, Yik M.

AU - Gredley, Matthew

AU - Bird, Graham J.

AU - Jackson, W. Roy

AU - Gountzos, Helen

AU - Matthews, Barry R.

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