Asymmetric induction in domino Heck-aza-Michael reactions

Daniel Priebbenow; Scott G Stewart; Frederick Matthew Pfeffer

doi:10.1016/j.tetlet.2012.01.037

Asymmetric induction in domino Heck-aza-Michael reactions

Daniel Priebbenow, Scott G Stewart, Frederick Matthew Pfeffer

Research output: Contribution to journal › Article › Research › peer-review

23 Citations (Scopus)

Abstract

Domino Heck-aza-Michael reactions are an efficient method for the rapid synthesis of functionalised N-heterocycles. An asymmetric version of this domino process has been developed to access chiral 1,3-disubstituted N-heterocycles from amino acid precursors in excellent yields (68-81 ) with moderate to high diastereoselectivity (up to 92 de).

Original language	English
Pages (from-to)	1468 - 1471
Number of pages	4
Journal	Tetrahedron Letters
Volume	53
Issue number	12
DOIs	https://doi.org/10.1016/j.tetlet.2012.01.037
Publication status	Published - 2012
Externally published	Yes

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10.1016/j.tetlet.2012.01.037

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title = "Asymmetric induction in domino Heck-aza-Michael reactions",

abstract = "Domino Heck-aza-Michael reactions are an efficient method for the rapid synthesis of functionalised N-heterocycles. An asymmetric version of this domino process has been developed to access chiral 1,3-disubstituted N-heterocycles from amino acid precursors in excellent yields (68-81 ) with moderate to high diastereoselectivity (up to 92 de).",

author = "Daniel Priebbenow and Stewart, \{Scott G\} and Pfeffer, \{Frederick Matthew\}",

year = "2012",

doi = "10.1016/j.tetlet.2012.01.037",

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AU - Priebbenow, Daniel

AU - Stewart, Scott G

AU - Pfeffer, Frederick Matthew

PY - 2012

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N2 - Domino Heck-aza-Michael reactions are an efficient method for the rapid synthesis of functionalised N-heterocycles. An asymmetric version of this domino process has been developed to access chiral 1,3-disubstituted N-heterocycles from amino acid precursors in excellent yields (68-81 ) with moderate to high diastereoselectivity (up to 92 de).

AB - Domino Heck-aza-Michael reactions are an efficient method for the rapid synthesis of functionalised N-heterocycles. An asymmetric version of this domino process has been developed to access chiral 1,3-disubstituted N-heterocycles from amino acid precursors in excellent yields (68-81 ) with moderate to high diastereoselectivity (up to 92 de).

UR - http://tinyurl.com/o7onskw

UR - https://www.scopus.com/pages/publications/84857237598

U2 - 10.1016/j.tetlet.2012.01.037

DO - 10.1016/j.tetlet.2012.01.037

M3 - Article

SN - 0040-4039

VL - 53

SP - 1468

EP - 1471

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 12

ER -

Asymmetric induction in domino Heck-aza-Michael reactions

Abstract

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