ASW

a gene with conserved avian W-linkage and female specific expression in chick embryonic gonad

Michael O'Neill, Michele Binder, Craig Smith, Jane Andrews, Kirsty Reed, Matthijs Smith, Craig Millar, David Lambert, Andrew Sinclair

Research output: Contribution to journalArticleResearchpeer-review

91 Citations (Scopus)

Abstract

Vertebrates exhibit a variety of sex determining mechanisms which fall broadly into two classes: environmental or genetic. In birds and mammals sex is determined by a genetic mechanism. In mammals males are the heterogametic sex (XY) with the Y chromosome acting as a dominant determiner of sex due to the action of the testis-determining factor, SRY. In birds females are the heterogametic sex (ZW); however, it is not known whether the W chromosome carries a dominant ovary-determining gene, or whether Z chromosome dosage determines sex. Using an experimental approach, which assumes only that the sex-determining event in birds is accompanied by sex-specific changes in gene expression, we have identified a novel gene, ASW (Avian Sex-specific W-linked). The putative protein for ASW is related to the HIT (histidine triad) family of proteins. ASW shows female-specific expression in genital ridges and maps to the chicken W chromosome. In addition, we show that, with the exception of ratites, ASW is linked to the W chromosome in each of 17 bird species from nine different families of the class Aves.

Original languageEnglish
Pages (from-to)243-249
Number of pages7
JournalDevelopment Genes and Evolution
Volume210
Issue number5
DOIs
Publication statusPublished - 13 May 2000
Externally publishedYes

Keywords

  • Avian W-chromosome
  • Female-specific
  • Gene expression
  • Gonad development

Cite this

O'Neill, Michael ; Binder, Michele ; Smith, Craig ; Andrews, Jane ; Reed, Kirsty ; Smith, Matthijs ; Millar, Craig ; Lambert, David ; Sinclair, Andrew. / ASW : a gene with conserved avian W-linkage and female specific expression in chick embryonic gonad. In: Development Genes and Evolution. 2000 ; Vol. 210, No. 5. pp. 243-249.
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abstract = "Vertebrates exhibit a variety of sex determining mechanisms which fall broadly into two classes: environmental or genetic. In birds and mammals sex is determined by a genetic mechanism. In mammals males are the heterogametic sex (XY) with the Y chromosome acting as a dominant determiner of sex due to the action of the testis-determining factor, SRY. In birds females are the heterogametic sex (ZW); however, it is not known whether the W chromosome carries a dominant ovary-determining gene, or whether Z chromosome dosage determines sex. Using an experimental approach, which assumes only that the sex-determining event in birds is accompanied by sex-specific changes in gene expression, we have identified a novel gene, ASW (Avian Sex-specific W-linked). The putative protein for ASW is related to the HIT (histidine triad) family of proteins. ASW shows female-specific expression in genital ridges and maps to the chicken W chromosome. In addition, we show that, with the exception of ratites, ASW is linked to the W chromosome in each of 17 bird species from nine different families of the class Aves.",
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O'Neill, M, Binder, M, Smith, C, Andrews, J, Reed, K, Smith, M, Millar, C, Lambert, D & Sinclair, A 2000, 'ASW: a gene with conserved avian W-linkage and female specific expression in chick embryonic gonad', Development Genes and Evolution, vol. 210, no. 5, pp. 243-249. https://doi.org/10.1007/s004270050310

ASW : a gene with conserved avian W-linkage and female specific expression in chick embryonic gonad. / O'Neill, Michael; Binder, Michele; Smith, Craig; Andrews, Jane; Reed, Kirsty; Smith, Matthijs; Millar, Craig; Lambert, David; Sinclair, Andrew.

In: Development Genes and Evolution, Vol. 210, No. 5, 13.05.2000, p. 243-249.

Research output: Contribution to journalArticleResearchpeer-review

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AU - O'Neill, Michael

AU - Binder, Michele

AU - Smith, Craig

AU - Andrews, Jane

AU - Reed, Kirsty

AU - Smith, Matthijs

AU - Millar, Craig

AU - Lambert, David

AU - Sinclair, Andrew

PY - 2000/5/13

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