Assuring high quality treatment delivery in clinical trials - Results from the Trans-Tasman Radiation Oncology Group (TROG) study 03.04 "RADAR" set-up accuracy study

Annette Haworth, Rachel Kearvell, Peter B Greer, Ben Hooton, James W Denham, David Lamb, Gillian Duchesne, Judy Murray, David Joseph

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)


Background and purpose: A multi-centre clinical trial for prostate cancer patients provided an opportunity to introduce conformal radiotherapy with dose escalation. To verify adequate treatment accuracy prior to patient recruitment, centres submitted details of a set-up accuracy study (SUAS). We report the results of the SUAS, the variation in clinical practice and the strategies used to help centres improve treatment accuracy. Materials and methods: The SUAS required each of the 24 participating centres to collect data on at least 10 pelvic patients imaged on a minimum of 20 occasions. Software was provided for data collection and analysis. Support to centres was provided through educational lectures, the trial quality assurance team and an information booklet. Results: Only two centres had recently carried out a SUAS prior to the trial opening. Systematic errors were generally smaller than those previously reported in the literature. The questionnaire identified many differences in patient set-up protocols. As a result of participating in this QA activity more than 65% of centres improved their treatment delivery accuracy. Conclusions: Conducting a pre-trial SUAS has led to improvement in treatment delivery accuracy in many centres. Treatment techniques and set-up accuracy varied greatly, demonstrating a need to ensure an on-going awareness for such studies in future trials and with the introduction of dose escalation or new technologies. Crown

Original languageEnglish
Pages (from-to)299-306
Number of pages8
JournalRadiotherapy and Oncology
Issue number3
Publication statusPublished - Mar 2009
Externally publishedYes


  • Clinical trials
  • Prostate
  • Quality assurance
  • Set-up accuracy

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