Associations of overall sitting time and TV viewing time with fibrinogen and C reactive protein

the AusDiab study

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19 Citations (Scopus)

Abstract

Background/aim: Sedentary behaviour is associated with increased risk for all-cause and cardiovascular mortality. Plasma fibrinogen and C reactive protein (CRP)-key inflammatory and/or haemostatic markers-may contribute to this association; however, few studies have examined their relationships with sedentary behaviours. We examined associations of overall sitting and TV viewing time with fibrinogen and high-sensitivity CRP (hsCRP). Methods: Plasma fibrinogen and hsCRP were measured in 3086 Australian adults (mean age: 55?12 years) who participated in the 2004-2005 AusDiab (Australian Diabetes, Obesity and Lifestyle) study. Multiple linear regression analyses examined cross-sectional associations of self-reported overall sitting and TV viewing time (h/day) with plasma fibrinogen and hsCRP, adjusting for sociodemographic, behavioural and medical treatments and conditions as potential covariates. Results: Overall sitting time and TV viewing time were positively associated with plasma fibrinogen (sitting: ?: 0.02 g/L, 95 CI (0.01 to 0.02); TV time: 0.03 g/L (0.02 to 0.05)) and hsCRP (sitting: 2.4 (1.2 to 3.6 ); TV time: 4.5 (1.7 to 7.4 )). Associations were independent of leisure-time physical activity, but after adjusting for waist circumference, they remained for fibrinogen, but for hsCRP were attenuated to the null. Interactions were observed for gender?TV (p=0.011) with fibrinogen (associations in women only) and for waist circumference?TV (p=0.084) with hsCRP (associations in low-risk only). Conclusions: Overall sitting time was positively associated with plasma fibrinogen and hsCRP in men and women; associations of TV viewing time with fibrinogen were observed in women only. Abdominal adiposity-mediated associations for hsCRP but not for fibrinogen. Prospective and intervention studies are needed to establish likely causality and elucidate potential mechanisms.
Original languageEnglish
Pages (from-to)255-258
Number of pages4
JournalBritish Journal of Sports Medicine
Volume49
Issue number4
DOIs
Publication statusPublished - 2015

Cite this

@article{36c3e028837a434ba5accaa01a20572e,
title = "Associations of overall sitting time and TV viewing time with fibrinogen and C reactive protein: the AusDiab study",
abstract = "Background/aim: Sedentary behaviour is associated with increased risk for all-cause and cardiovascular mortality. Plasma fibrinogen and C reactive protein (CRP)-key inflammatory and/or haemostatic markers-may contribute to this association; however, few studies have examined their relationships with sedentary behaviours. We examined associations of overall sitting and TV viewing time with fibrinogen and high-sensitivity CRP (hsCRP). Methods: Plasma fibrinogen and hsCRP were measured in 3086 Australian adults (mean age: 55?12 years) who participated in the 2004-2005 AusDiab (Australian Diabetes, Obesity and Lifestyle) study. Multiple linear regression analyses examined cross-sectional associations of self-reported overall sitting and TV viewing time (h/day) with plasma fibrinogen and hsCRP, adjusting for sociodemographic, behavioural and medical treatments and conditions as potential covariates. Results: Overall sitting time and TV viewing time were positively associated with plasma fibrinogen (sitting: ?: 0.02 g/L, 95 CI (0.01 to 0.02); TV time: 0.03 g/L (0.02 to 0.05)) and hsCRP (sitting: 2.4 (1.2 to 3.6 ); TV time: 4.5 (1.7 to 7.4 )). Associations were independent of leisure-time physical activity, but after adjusting for waist circumference, they remained for fibrinogen, but for hsCRP were attenuated to the null. Interactions were observed for gender?TV (p=0.011) with fibrinogen (associations in women only) and for waist circumference?TV (p=0.084) with hsCRP (associations in low-risk only). Conclusions: Overall sitting time was positively associated with plasma fibrinogen and hsCRP in men and women; associations of TV viewing time with fibrinogen were observed in women only. Abdominal adiposity-mediated associations for hsCRP but not for fibrinogen. Prospective and intervention studies are needed to establish likely causality and elucidate potential mechanisms.",
author = "Bethany Howard and Beverley Balkau and Thorp, {Alicia A} and Magliano, {Dianna Josephine} and Shaw, {Jonathan E} and Neville Owen and Dunstan, {David W}",
year = "2015",
doi = "10.1136/bjsports-2013-093014",
language = "English",
volume = "49",
pages = "255--258",
journal = "British Journal of Sports Medicine",
issn = "0306-3674",
publisher = "BMJ Publishing Group",
number = "4",

}

TY - JOUR

T1 - Associations of overall sitting time and TV viewing time with fibrinogen and C reactive protein

T2 - the AusDiab study

AU - Howard, Bethany

AU - Balkau, Beverley

AU - Thorp, Alicia A

AU - Magliano, Dianna Josephine

AU - Shaw, Jonathan E

AU - Owen, Neville

AU - Dunstan, David W

PY - 2015

Y1 - 2015

N2 - Background/aim: Sedentary behaviour is associated with increased risk for all-cause and cardiovascular mortality. Plasma fibrinogen and C reactive protein (CRP)-key inflammatory and/or haemostatic markers-may contribute to this association; however, few studies have examined their relationships with sedentary behaviours. We examined associations of overall sitting and TV viewing time with fibrinogen and high-sensitivity CRP (hsCRP). Methods: Plasma fibrinogen and hsCRP were measured in 3086 Australian adults (mean age: 55?12 years) who participated in the 2004-2005 AusDiab (Australian Diabetes, Obesity and Lifestyle) study. Multiple linear regression analyses examined cross-sectional associations of self-reported overall sitting and TV viewing time (h/day) with plasma fibrinogen and hsCRP, adjusting for sociodemographic, behavioural and medical treatments and conditions as potential covariates. Results: Overall sitting time and TV viewing time were positively associated with plasma fibrinogen (sitting: ?: 0.02 g/L, 95 CI (0.01 to 0.02); TV time: 0.03 g/L (0.02 to 0.05)) and hsCRP (sitting: 2.4 (1.2 to 3.6 ); TV time: 4.5 (1.7 to 7.4 )). Associations were independent of leisure-time physical activity, but after adjusting for waist circumference, they remained for fibrinogen, but for hsCRP were attenuated to the null. Interactions were observed for gender?TV (p=0.011) with fibrinogen (associations in women only) and for waist circumference?TV (p=0.084) with hsCRP (associations in low-risk only). Conclusions: Overall sitting time was positively associated with plasma fibrinogen and hsCRP in men and women; associations of TV viewing time with fibrinogen were observed in women only. Abdominal adiposity-mediated associations for hsCRP but not for fibrinogen. Prospective and intervention studies are needed to establish likely causality and elucidate potential mechanisms.

AB - Background/aim: Sedentary behaviour is associated with increased risk for all-cause and cardiovascular mortality. Plasma fibrinogen and C reactive protein (CRP)-key inflammatory and/or haemostatic markers-may contribute to this association; however, few studies have examined their relationships with sedentary behaviours. We examined associations of overall sitting and TV viewing time with fibrinogen and high-sensitivity CRP (hsCRP). Methods: Plasma fibrinogen and hsCRP were measured in 3086 Australian adults (mean age: 55?12 years) who participated in the 2004-2005 AusDiab (Australian Diabetes, Obesity and Lifestyle) study. Multiple linear regression analyses examined cross-sectional associations of self-reported overall sitting and TV viewing time (h/day) with plasma fibrinogen and hsCRP, adjusting for sociodemographic, behavioural and medical treatments and conditions as potential covariates. Results: Overall sitting time and TV viewing time were positively associated with plasma fibrinogen (sitting: ?: 0.02 g/L, 95 CI (0.01 to 0.02); TV time: 0.03 g/L (0.02 to 0.05)) and hsCRP (sitting: 2.4 (1.2 to 3.6 ); TV time: 4.5 (1.7 to 7.4 )). Associations were independent of leisure-time physical activity, but after adjusting for waist circumference, they remained for fibrinogen, but for hsCRP were attenuated to the null. Interactions were observed for gender?TV (p=0.011) with fibrinogen (associations in women only) and for waist circumference?TV (p=0.084) with hsCRP (associations in low-risk only). Conclusions: Overall sitting time was positively associated with plasma fibrinogen and hsCRP in men and women; associations of TV viewing time with fibrinogen were observed in women only. Abdominal adiposity-mediated associations for hsCRP but not for fibrinogen. Prospective and intervention studies are needed to establish likely causality and elucidate potential mechanisms.

UR - http://bjsm.bmj.com/content/49/4/255.full.pdf

U2 - 10.1136/bjsports-2013-093014

DO - 10.1136/bjsports-2013-093014

M3 - Article

VL - 49

SP - 255

EP - 258

JO - British Journal of Sports Medicine

JF - British Journal of Sports Medicine

SN - 0306-3674

IS - 4

ER -