Abstract
| Original language | English |
|---|---|
| Article number | 1370 |
| Number of pages | 13 |
| Journal | Journal of Clinical Medicine |
| Volume | 8 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 2019 |
Cite this
}
Associations of health-related quality of life, fear of falling and objective measures of physical function with bone health in postmenopausal women with low bone mass. / Gandham, Anoohya; McMillan, Lachlan; Ng, Carrie-Anne; Humbert, Ludovic ; Bonham, Maxine; Zengin, Ayse; Ebeling, Peter; Scott, David.
In: Journal of Clinical Medicine, Vol. 8, No. 9, 1370, 09.2019.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Associations of health-related quality of life, fear of falling and objective measures of physical function with bone health in postmenopausal women with low bone mass
AU - Gandham, Anoohya
AU - McMillan, Lachlan
AU - Ng, Carrie-Anne
AU - Humbert, Ludovic
AU - Bonham, Maxine
AU - Zengin, Ayse
AU - Ebeling, Peter
AU - Scott, David
PY - 2019/9
Y1 - 2019/9
N2 - Health-related quality of life (HRQoL) and physical function deteriorate with age and may adversely impact bone health in older adults. We determined associations of objective measures of physical function and HRQoL with bone health in postmenopausal women with low areal bone mineral density (aBMD). Fifty postmenopausal women (64.4 7.7 years old, mean standard deviation) with low spine, hip or femoral neck aBMD (T- or Z-score < -1.0) on dual-energy X-ray absorptiometry (DXA) participated. Femoral surface BMD, trabecular, integral and cortical volumetric BMD (vBMD) measurements were obtained using 3D-SHAPER software on DXA. Distal tibial vBMD and microarchitecture were assessed using high-resolution peripheral quantitative computed tomography (HRpQCT). Participants completed self-administered EuroQol-5D (EQ-5D) and modified falls efficacy scale (MFES) questionnaires, and physical function assessments. Stair climb power was positively associated with bone parameters at the hip, femoral neck, and distal tibia (all p < 0.05) in multivariable linear regression. EQ-5D demonstrated no significant associations with bone parameters and MFES was positively associated only with distal tibial cortical vBMD and cortical von Mises stress (both p < 0.05). Objective measures of physical function, particularly muscle power, are more consistently associated with bone parameters compared with self-administered HRQoL questionnaires.
AB - Health-related quality of life (HRQoL) and physical function deteriorate with age and may adversely impact bone health in older adults. We determined associations of objective measures of physical function and HRQoL with bone health in postmenopausal women with low areal bone mineral density (aBMD). Fifty postmenopausal women (64.4 7.7 years old, mean standard deviation) with low spine, hip or femoral neck aBMD (T- or Z-score < -1.0) on dual-energy X-ray absorptiometry (DXA) participated. Femoral surface BMD, trabecular, integral and cortical volumetric BMD (vBMD) measurements were obtained using 3D-SHAPER software on DXA. Distal tibial vBMD and microarchitecture were assessed using high-resolution peripheral quantitative computed tomography (HRpQCT). Participants completed self-administered EuroQol-5D (EQ-5D) and modified falls efficacy scale (MFES) questionnaires, and physical function assessments. Stair climb power was positively associated with bone parameters at the hip, femoral neck, and distal tibia (all p < 0.05) in multivariable linear regression. EQ-5D demonstrated no significant associations with bone parameters and MFES was positively associated only with distal tibial cortical vBMD and cortical von Mises stress (both p < 0.05). Objective measures of physical function, particularly muscle power, are more consistently associated with bone parameters compared with self-administered HRQoL questionnaires.
U2 - 10.3390/jcm8091370
DO - 10.3390/jcm8091370
M3 - Article
VL - 8
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
SN - 2077-0383
IS - 9
M1 - 1370
ER -