Associations of calf inter- and intra-muscular adipose tissue with cardiometabolic health and physical function in community-dwelling older adults

David Stephen Scott, T Trbojevic, Elizabeth Skinner, Ross Allan Clark, Pazit T Levinger, Terrence Peter Haines, Kerrie Margaret Sanders, Peter Robert Ebeling

Research output: Contribution to journalArticleResearchpeer-review

Abstract

OBJECTIVES: To determine associations of inter- and intra-muscular adipose tissue (IMAT) with cardiometabolic health and physical function in older adults. METHODS: 48 community-dwelling older adults aged =/>65 years (mean 71.6+/-4.8 years; 52 women) underwent whole-body dual-energy X-ray absorptiometry, to assess appendicular lean mass (ALM), and peripheral quantitative computed tomography (pQCT; 66 tibia), to assess calf IMAT cross-sectional area ([CSA]; cm(2)) and muscle density (mg/cm(3); higher values indicate lower fat infiltration). Fasting glucose, lipids, triglycerides and C-reactive protein (CRP) were analysed. Physical function was assessed by postural sway (computerised posturography; N=41), and gait analysis (GAITRite Electronic Walkway; N=40). RESULTS: Higher IMAT CSA and muscle density were associated with significantly higher (B=0.85 95 CI [0.34, 1.36]) and lower (-2.14 [-4.20, -0.08]) CRP and higher (0.93 [0.56, 1.30]) and lower postural sway (-3.12 [-4.74, -1.50]), respectively, after adjustment for age, sex and ALM/BMI. Higher IMAT CSA was associated with slower gait speed and cadence, and greater step time and step width (all P
Original languageEnglish
Pages (from-to)350 - 357
Number of pages8
JournalJournal of Musculoskeletal Neuronal Interactions
Volume15
Issue number4
Publication statusPublished - 2015

Cite this

@article{2131920291054c4caf8e51dcdc1e2ef1,
title = "Associations of calf inter- and intra-muscular adipose tissue with cardiometabolic health and physical function in community-dwelling older adults",
abstract = "OBJECTIVES: To determine associations of inter- and intra-muscular adipose tissue (IMAT) with cardiometabolic health and physical function in older adults. METHODS: 48 community-dwelling older adults aged =/>65 years (mean 71.6+/-4.8 years; 52 women) underwent whole-body dual-energy X-ray absorptiometry, to assess appendicular lean mass (ALM), and peripheral quantitative computed tomography (pQCT; 66 tibia), to assess calf IMAT cross-sectional area ([CSA]; cm(2)) and muscle density (mg/cm(3); higher values indicate lower fat infiltration). Fasting glucose, lipids, triglycerides and C-reactive protein (CRP) were analysed. Physical function was assessed by postural sway (computerised posturography; N=41), and gait analysis (GAITRite Electronic Walkway; N=40). RESULTS: Higher IMAT CSA and muscle density were associated with significantly higher (B=0.85 95 CI [0.34, 1.36]) and lower (-2.14 [-4.20, -0.08]) CRP and higher (0.93 [0.56, 1.30]) and lower postural sway (-3.12 [-4.74, -1.50]), respectively, after adjustment for age, sex and ALM/BMI. Higher IMAT CSA was associated with slower gait speed and cadence, and greater step time and step width (all P",
author = "Scott, {David Stephen} and T Trbojevic and Elizabeth Skinner and Clark, {Ross Allan} and Levinger, {Pazit T} and Haines, {Terrence Peter} and Sanders, {Kerrie Margaret} and Ebeling, {Peter Robert}",
year = "2015",
language = "English",
volume = "15",
pages = "350 -- 357",
journal = "Journal of Musculoskeletal Neuronal Interactions",
issn = "1108-7161",
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}

Associations of calf inter- and intra-muscular adipose tissue with cardiometabolic health and physical function in community-dwelling older adults. / Scott, David Stephen; Trbojevic, T; Skinner, Elizabeth; Clark, Ross Allan; Levinger, Pazit T; Haines, Terrence Peter; Sanders, Kerrie Margaret; Ebeling, Peter Robert.

In: Journal of Musculoskeletal Neuronal Interactions, Vol. 15, No. 4, 2015, p. 350 - 357.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Associations of calf inter- and intra-muscular adipose tissue with cardiometabolic health and physical function in community-dwelling older adults

AU - Scott, David Stephen

AU - Trbojevic, T

AU - Skinner, Elizabeth

AU - Clark, Ross Allan

AU - Levinger, Pazit T

AU - Haines, Terrence Peter

AU - Sanders, Kerrie Margaret

AU - Ebeling, Peter Robert

PY - 2015

Y1 - 2015

N2 - OBJECTIVES: To determine associations of inter- and intra-muscular adipose tissue (IMAT) with cardiometabolic health and physical function in older adults. METHODS: 48 community-dwelling older adults aged =/>65 years (mean 71.6+/-4.8 years; 52 women) underwent whole-body dual-energy X-ray absorptiometry, to assess appendicular lean mass (ALM), and peripheral quantitative computed tomography (pQCT; 66 tibia), to assess calf IMAT cross-sectional area ([CSA]; cm(2)) and muscle density (mg/cm(3); higher values indicate lower fat infiltration). Fasting glucose, lipids, triglycerides and C-reactive protein (CRP) were analysed. Physical function was assessed by postural sway (computerised posturography; N=41), and gait analysis (GAITRite Electronic Walkway; N=40). RESULTS: Higher IMAT CSA and muscle density were associated with significantly higher (B=0.85 95 CI [0.34, 1.36]) and lower (-2.14 [-4.20, -0.08]) CRP and higher (0.93 [0.56, 1.30]) and lower postural sway (-3.12 [-4.74, -1.50]), respectively, after adjustment for age, sex and ALM/BMI. Higher IMAT CSA was associated with slower gait speed and cadence, and greater step time and step width (all P

AB - OBJECTIVES: To determine associations of inter- and intra-muscular adipose tissue (IMAT) with cardiometabolic health and physical function in older adults. METHODS: 48 community-dwelling older adults aged =/>65 years (mean 71.6+/-4.8 years; 52 women) underwent whole-body dual-energy X-ray absorptiometry, to assess appendicular lean mass (ALM), and peripheral quantitative computed tomography (pQCT; 66 tibia), to assess calf IMAT cross-sectional area ([CSA]; cm(2)) and muscle density (mg/cm(3); higher values indicate lower fat infiltration). Fasting glucose, lipids, triglycerides and C-reactive protein (CRP) were analysed. Physical function was assessed by postural sway (computerised posturography; N=41), and gait analysis (GAITRite Electronic Walkway; N=40). RESULTS: Higher IMAT CSA and muscle density were associated with significantly higher (B=0.85 95 CI [0.34, 1.36]) and lower (-2.14 [-4.20, -0.08]) CRP and higher (0.93 [0.56, 1.30]) and lower postural sway (-3.12 [-4.74, -1.50]), respectively, after adjustment for age, sex and ALM/BMI. Higher IMAT CSA was associated with slower gait speed and cadence, and greater step time and step width (all P

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EP - 357

JO - Journal of Musculoskeletal Neuronal Interactions

JF - Journal of Musculoskeletal Neuronal Interactions

SN - 1108-7161

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