TY - JOUR
T1 - Associations of body mass index, body fat percentage and sarcopenia components with bone health estimated by second-generation high-resolution peripheral quantitative computed tomography in older adults with obesity
AU - Gandham, Anoohya
AU - Mesinovic, Jakub
AU - Cervo, Mavil May
AU - Glavas, Costas
AU - Jansons, Paul
AU - Ng, Carrie Anne
AU - Rodriguez, Juan Pena
AU - Zengin, Ayse
AU - Bonham, Maxine P.
AU - Ebeling, Peter R.
AU - Scott, David
N1 - Funding Information:
This work was supported by a 2018 Rebecca L. Cooper Foundation-Project Grant and 2017 American Society of Bone and Mineral Research Rising Star Award awarded to Dr. David Scott, and Monash University's School of Clinical Sciences “Near-Miss” grant Scheme awarded to Professor Peter Ebeling. Dr. David Scott is supported by an Australian National Health and Medical Research Council (NHMRC) Investigator Grant ( GNT1174886 ).
Publisher Copyright:
© 2023
PY - 2023/8
Y1 - 2023/8
N2 - Purpose: To investigate associations between body mass index (BMI), body fat percentage, and components of sarcopenia (muscle mass and muscle strength/power), with bone microarchitecture measured by high-resolution peripheral computed tomography (HR-pQCT) in older adults with obesity. Methods: Seventy-four adults aged ≥ 55 years with body fat percentage ≥ 30 % (men) or ≥40 % (women) were included. Fat mass, lean mass and total hip, femoral neck, and lumbar spine areal bone mineral density (aBMD) were measured by dual-energy X-ray absorptiometry. Appendicular lean mass (ALM) was calculated as the sum of lean mass in the upper- and lower-limbs. BMI was calculated and participants completed physical function assessments including stair climb power test. Distal tibial bone microarchitecture was assessed using HR-pQCT. Linear regression (β-coefficients and 95 % confidence intervals) analyses were performed with adjustment for confounders including age, sex, smoking status, vitamin D and self-reported moderate to vigorous physical activity. Results: BMI and ALM/height2 were both positively associated with total hip, femoral neck and lumbar spine aBMD and trabecular bone volume fraction after adjusting for confounders (all p < 0.05). Body fat percentage was not associated with aBMD or any trabecular bone parameters but was negatively associated with cortical area (p < 0.05). Stair climb power (indicating better performance) was positively associated with cortical area and negatively associated with bone failure load (both p < 0.05). Conclusion: Higher BMI, ALM/height2 and muscle power were associated with more favourable bone microarchitecture, but higher body fat percentage was negatively associated with cortical bone area. These findings suggest that high BMI may be protective for fractures and that this might be attributable to higher muscle mass and/or forces, while higher relative body fat is not associated with better bone health in older adults with obesity.
AB - Purpose: To investigate associations between body mass index (BMI), body fat percentage, and components of sarcopenia (muscle mass and muscle strength/power), with bone microarchitecture measured by high-resolution peripheral computed tomography (HR-pQCT) in older adults with obesity. Methods: Seventy-four adults aged ≥ 55 years with body fat percentage ≥ 30 % (men) or ≥40 % (women) were included. Fat mass, lean mass and total hip, femoral neck, and lumbar spine areal bone mineral density (aBMD) were measured by dual-energy X-ray absorptiometry. Appendicular lean mass (ALM) was calculated as the sum of lean mass in the upper- and lower-limbs. BMI was calculated and participants completed physical function assessments including stair climb power test. Distal tibial bone microarchitecture was assessed using HR-pQCT. Linear regression (β-coefficients and 95 % confidence intervals) analyses were performed with adjustment for confounders including age, sex, smoking status, vitamin D and self-reported moderate to vigorous physical activity. Results: BMI and ALM/height2 were both positively associated with total hip, femoral neck and lumbar spine aBMD and trabecular bone volume fraction after adjusting for confounders (all p < 0.05). Body fat percentage was not associated with aBMD or any trabecular bone parameters but was negatively associated with cortical area (p < 0.05). Stair climb power (indicating better performance) was positively associated with cortical area and negatively associated with bone failure load (both p < 0.05). Conclusion: Higher BMI, ALM/height2 and muscle power were associated with more favourable bone microarchitecture, but higher body fat percentage was negatively associated with cortical bone area. These findings suggest that high BMI may be protective for fractures and that this might be attributable to higher muscle mass and/or forces, while higher relative body fat is not associated with better bone health in older adults with obesity.
KW - Bone
KW - Muscle
KW - Obesity
KW - Older adults
UR - http://www.scopus.com/inward/record.url?scp=85161640451&partnerID=8YFLogxK
U2 - 10.1016/j.exger.2023.112227
DO - 10.1016/j.exger.2023.112227
M3 - Article
C2 - 37263367
AN - SCOPUS:85161640451
SN - 0531-5565
VL - 179
JO - Experimental Gerontology
JF - Experimental Gerontology
M1 - 112227
ER -
