Associations between urinary advanced glycation end products and cardiometabolic parameters in metabolically healthy obese women

Estifanos Baye, Alicja B Mark, Malene W Poulsen, Jeanette M Andersen, Lars O Dragsted, Sussanne G Bügel, Barbora de Courten

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Abstract

Advanced glycation end products (AGEs) have been implicated in the pathophysiology of type 2 diabetes and cardiovascular disease. We aimed to determine the associations of urinary carboxymethyl-lysine (CML) and methylglyoxal-hydroimidazolone (MG-H1) levels with cardiometabolic parameters in metabolically healthy obese women. Anthropometric, glycemic, cardiovascular, and urinary AGE parameters were measured in 58 metabolically healthy obese women (age: 39.98 ± 8.72 years; body mass index (BMI): 32.29 ± 4.05 kg/m2 ). Urinary CML levels were positively associated with BMI (r = 0.29, p = 0.02). After adjustment for age and BMI, there was a trend for positive associations between urinary CML levels and fasting (p = 0.06) and 2 h insulin (p = 0.05) levels, and insulin resistance measured by homeostatic model assessment (HOMA-IR) (p = 0.06). Urinary MG-H1 levels were positively associated with systolic and diastolic blood pressure, pulse pressure, mean arterial pressure, and total and low-density lipoprotein cholesterol after adjustment for age, BMI, and HOMA-IR (all p < 0.05). There were no associations between urinary CML levels and cardiovascular parameters, and between urinary MG-H1 levels and glycemic measurements. Our data support a role of urinary AGEs in the pathophysiology of insulin resistance and cardiovascular disease; however, future studies are highly warranted.
Original languageEnglish
Article number1008
Number of pages8
JournalJournal of Clinical Medicine
Volume8
Issue number7
DOIs
Publication statusPublished - 10 Jul 2019

Keywords

  • advanced glycation end products
  • carboxymethyl-lysine
  • methylglyoxal-derived hydroimidazolone
  • insulin resistance
  • type 2 diabetes
  • cardiovascular disease

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