Associations between measures of adiposity over 10 years and patella cartilage in population-based asymptomatic women

Alberta Jesslyn Gunardi, Sharon Lee Brennan, YuanYuan Wang, Flavia Maria Cicuttini, Julie Anne Pasco, Mark Kotowicz, Geoffrey C Nicholson, Anita Estelle Wluka

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

Osteoarthritis (OA) most commonly affects the patellofemoral compartment of the knee, and is a major cause of pain and disability. Structural changes that evolve prior to the onset of symptoms can be visualised using magnetic resonance imaging (MRI). There is little known information about the role of adiposity on the early structural changes in the patella cartilage in younger, asymptomatic adult females.Methods:One hundred and sixty asymptomatic women (20-49 years) participating in the Geelong Osteoporosis Study underwent knee MRI (2006-8). Weight and body mass index (BMI) were measured 10 years prior (1994-7, baseline) and at the time of MRI (current), with change over the period calculated (current-baseline). Relationships between measures of adiposity and patella cartilage volume and defects were examined.Results:After adjustment for age and patella bone volume, there was a reduction of 13 ml (95 confidence interval (95 CI),-25.7,-0.55) in patella cartilage volume for every 1 unit increase in current BMI, and a reduction of 27 ml (95 CI-52.6,-1.5) per BMI unit increase over 10 years (P=0.04 for both). No significant association was observed between baseline BMI and patella cartilage volume (P=0.16). Increased baseline and current weight and BMI were associated with increased prevalence of patella cartilage defects (all P
Original languageEnglish
Pages (from-to)1586 - 1589
Number of pages4
JournalInternational Journal of Obesity
Volume37
Issue number12
DOIs
Publication statusPublished - 2013

Cite this