Associations between anxious-depressed symptoms and cardiovascular risk factors in a longitudinal childhood study

Sandra Louise, Nicole M Warrington, Pamela A. McCaskie, Wendy H. Oddy, Stephen R. Zubrick, Kim Beth Hands, Trevor A. Mori, Laurent Briollais, Sven R. Silburn, Lyle J Palmer, Eugen Mattes, Lawrence J. Beilin

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14 Citations (Scopus)


Objective: To examine the influence of anxious/depressed scores on cardiovascular risk factors throughout childhood. Methods: Data from the Western Australian Pregnancy Cohort (Raine) Study, a study of 2900 pregnancies recruited between 1989 and 1991, were used. Anxious-depressed scores (derived from the Childhood Behavior Checklist), body mass index (BMI) and blood pressure were measured at 5 (n = 1681), 8 (n = 1697), 10 (n = 1575) and 14 (n = 1386) years. At age 14 depressive symptom scores (Beck Depression Inventory for Youth), anxious-depressed scores (Youth Self-Report (YSR) and Teacher Report Form (TRF)) and fasting lipid, glucose and insulin were also available. Cross sectional and longitudinal analyses were conducted. Results: At age 14, girls with higher anxious-depressed scores had higher BMI (p≤0.005) and homeostasis model assessment-estimated insulin resistance (p≤0.0001). This equated to a difference of 0.6kg/m 2 and 0.3 units in predicted BMI and HOMA-IR respectively (top 5% vs. score of zero). Boys with higher anxious-depressed scores had lower systolic blood pressure trajectories (p=0.024). Conclusion: Depressive scores appear to have differing influences on BMI, homeostasis model assessment-estimated insulin resistance and systolic blood pressure in boys and girls. Paradoxically boys with higher anxious-depressed scores had lower blood pressure throughout childhood.

Original languageEnglish
Pages (from-to)345-350
Number of pages6
JournalPreventive Medicine
Issue number5
Publication statusPublished - 1 May 2012
Externally publishedYes


  • Cardiovascular disease
  • Child
  • Depression
  • Lifestyle
  • Risk factors

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