Associations between antral ovarian follicle dynamics and hormone production throughout the menstrual cycle as women age

Heidi Katherina Vanden Brink, David Robertson, Hyun Ja Lim, Chel Hee Lee, Donna R Chizen, Guy Harris, Georgina E Hale, Henry G Burger, Angela Baerwald

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The physiologic origins of age-related changes in hormone production during the menstrual cycle are uncertain. OBJECTIVE: To test the hypothesis that changes in antral follicle dynamics are associated with changes in hormone production as women age. METHODS: A prospective, observational study was conducted in ovulatory women of Mid-Reproductive Age (MRA; 18-35 years; n=10) and Advanced Reproductive Age (ARA; 45-55 years; n=20). The numbers and diameters of all follicles >/=2 mm were quantified ultrasonographically every 1-3 days for one interovulatory interval; the growth profiles of individually identified follicles >/= 4 mm were tabulated. Blood samples were assayed for FSH, LH, estradiol, progesterone, inhibin A and B, and AMH. RESULTS: 50 of women in both MRA and ARA groups developed 1-2 luteal phase dominant follicles (LPDFs). MRA women with typical LPDFs had greater luteal phase inhibin B (44.2 vs 17.0 ng/L) and estradiol (91.3 vs 51.7 ng/L) compared to those without LPDFs (p
Original languageEnglish
Pages (from-to)4553 - 4562
Number of pages10
JournalJournal of Clinical Endocrinology and Metabolism
Volume100
Issue number12
DOIs
Publication statusPublished - 2015

Cite this

Brink, Heidi Katherina Vanden ; Robertson, David ; Lim, Hyun Ja ; Lee, Chel Hee ; Chizen, Donna R ; Harris, Guy ; Hale, Georgina E ; Burger, Henry G ; Baerwald, Angela. / Associations between antral ovarian follicle dynamics and hormone production throughout the menstrual cycle as women age. In: Journal of Clinical Endocrinology and Metabolism. 2015 ; Vol. 100, No. 12. pp. 4553 - 4562.
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abstract = "The physiologic origins of age-related changes in hormone production during the menstrual cycle are uncertain. OBJECTIVE: To test the hypothesis that changes in antral follicle dynamics are associated with changes in hormone production as women age. METHODS: A prospective, observational study was conducted in ovulatory women of Mid-Reproductive Age (MRA; 18-35 years; n=10) and Advanced Reproductive Age (ARA; 45-55 years; n=20). The numbers and diameters of all follicles >/=2 mm were quantified ultrasonographically every 1-3 days for one interovulatory interval; the growth profiles of individually identified follicles >/= 4 mm were tabulated. Blood samples were assayed for FSH, LH, estradiol, progesterone, inhibin A and B, and AMH. RESULTS: 50 of women in both MRA and ARA groups developed 1-2 luteal phase dominant follicles (LPDFs). MRA women with typical LPDFs had greater luteal phase inhibin B (44.2 vs 17.0 ng/L) and estradiol (91.3 vs 51.7 ng/L) compared to those without LPDFs (p",
author = "Brink, {Heidi Katherina Vanden} and David Robertson and Lim, {Hyun Ja} and Lee, {Chel Hee} and Chizen, {Donna R} and Guy Harris and Hale, {Georgina E} and Burger, {Henry G} and Angela Baerwald",
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Associations between antral ovarian follicle dynamics and hormone production throughout the menstrual cycle as women age. / Brink, Heidi Katherina Vanden; Robertson, David; Lim, Hyun Ja; Lee, Chel Hee; Chizen, Donna R; Harris, Guy; Hale, Georgina E; Burger, Henry G; Baerwald, Angela.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 100, No. 12, 2015, p. 4553 - 4562.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Brink, Heidi Katherina Vanden

AU - Robertson, David

AU - Lim, Hyun Ja

AU - Lee, Chel Hee

AU - Chizen, Donna R

AU - Harris, Guy

AU - Hale, Georgina E

AU - Burger, Henry G

AU - Baerwald, Angela

PY - 2015

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N2 - The physiologic origins of age-related changes in hormone production during the menstrual cycle are uncertain. OBJECTIVE: To test the hypothesis that changes in antral follicle dynamics are associated with changes in hormone production as women age. METHODS: A prospective, observational study was conducted in ovulatory women of Mid-Reproductive Age (MRA; 18-35 years; n=10) and Advanced Reproductive Age (ARA; 45-55 years; n=20). The numbers and diameters of all follicles >/=2 mm were quantified ultrasonographically every 1-3 days for one interovulatory interval; the growth profiles of individually identified follicles >/= 4 mm were tabulated. Blood samples were assayed for FSH, LH, estradiol, progesterone, inhibin A and B, and AMH. RESULTS: 50 of women in both MRA and ARA groups developed 1-2 luteal phase dominant follicles (LPDFs). MRA women with typical LPDFs had greater luteal phase inhibin B (44.2 vs 17.0 ng/L) and estradiol (91.3 vs 51.7 ng/L) compared to those without LPDFs (p

AB - The physiologic origins of age-related changes in hormone production during the menstrual cycle are uncertain. OBJECTIVE: To test the hypothesis that changes in antral follicle dynamics are associated with changes in hormone production as women age. METHODS: A prospective, observational study was conducted in ovulatory women of Mid-Reproductive Age (MRA; 18-35 years; n=10) and Advanced Reproductive Age (ARA; 45-55 years; n=20). The numbers and diameters of all follicles >/=2 mm were quantified ultrasonographically every 1-3 days for one interovulatory interval; the growth profiles of individually identified follicles >/= 4 mm were tabulated. Blood samples were assayed for FSH, LH, estradiol, progesterone, inhibin A and B, and AMH. RESULTS: 50 of women in both MRA and ARA groups developed 1-2 luteal phase dominant follicles (LPDFs). MRA women with typical LPDFs had greater luteal phase inhibin B (44.2 vs 17.0 ng/L) and estradiol (91.3 vs 51.7 ng/L) compared to those without LPDFs (p

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