Association of waist circumference with impaired six-minute walk in type 2 diabetes mellitus is independent of cardiac function

Ying Wang, Hong Yang, Mark Nolan, Kazuaki Negishi, John Burgess, Thomas H. Marwick

Research output: Contribution to journalArticleResearchpeer-review


Subclinical left ventricular dysfunction has been associated with impaired exercise capacity in type 2 diabetes mellitus. In this community-based study of 274 asymptomatic T2DM patients (71 ± 4 years, 55% men) with preserved ejection fraction, a comprehensive resting echocardiogram was performed to gather sensitive systolic and diastolic function parameters (including speckle tracking echocardiography), and a standard six-minute walk test was performed. Tertiles of increasing waist circumference were associated with worsening walk distance. In this community-based study, we found an association of waist circumference with impaired exercise capacity, independent of age, gender, diabetes duration, insulin and angiotensin blockade, LV mass, systolic and diastolic function.

Original languageEnglish
Pages (from-to)542-544
Number of pages3
JournalJournal of Diabetes and its Complications
Issue number3
Publication statusPublished - Apr 2016
Externally publishedYes


  • Diabetes
  • Exercise capacity
  • Left ventricular dysfunction
  • Six-minute walk test
  • Waist circumference

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