Association of UCP2 -866G>A polymorphism with nonalcoholic fatty liver disease in patients from North-West of Iran

Fatemeh Mohseni; Safar Farajnia; Mahdieh Abbasalizad Farhangi; Manouchehr Khoshbaten; Mohammad Asghari Jafarabadi

doi:10.1093/labmed/lmw052

Association of UCP2 -866G>A polymorphism with nonalcoholic fatty liver disease in patients from North-West of Iran

Fatemeh Mohseni
, Safar Farajnia
, Mahdieh Abbasalizad Farhangi
, Manouchehr Khoshbaten
, Mohammad Asghari Jafarabadi

Research output: Contribution to journal › Article › Research › peer-review

4 Citations (Scopus)

Abstract

Objective: To investigate the association of uncoupling protein-2 (UCP2) -866G>A gene polymorphism (rs659366) with nonalcoholic fatty liver disease (NAFLD). Methods: We performed a case-control study with a cohort of 75 patients with NAFLD (of Iranian ethnicity) and 76 healthy individuals of Iranian ethnicity. The UCP2 -866G>A polymorphism (rs659366) was determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: Patients with AA and AG genotypes were 71% and 68%, respectively, more likely to have NAFLD, compared with individuals with the GG genotype (reference group). In subjects with a GG genotype, serum triglyceride (TG) concentration was significantly higher in patients with NAFLD (P=.04). Serum alanine aminotransferase (ALT) concentrations in all 3 genotypes and serum aspartate aminotransferase (AST) concentrations in AG and GG genotypes of UCP2 gene polymorphism were significantly higher in patients (P <.05). Conclusion: Our results revealed a modest modifier effect of -866G>A UCP2 polymorphism in patients with NAFLD.

Original language	English
Pages (from-to)	65-72
Number of pages	8
Journal	Laboratory Medicine
Volume	48
Issue number	1
DOIs	https://doi.org/10.1093/labmed/lmw052
Publication status	Published - Feb 2017
Externally published	Yes

Keywords

-866G>A polymorphism
Anthropometric indices
Biochemical parameters
Nonalcoholic fatty liver disease (NAFLD)
Uncoupling protein 2 (UCP2) gene

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10.1093/labmed/lmw052

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title = "Association of UCP2 -866G>A polymorphism with nonalcoholic fatty liver disease in patients from North-West of Iran",

abstract = "Objective: To investigate the association of uncoupling protein-2 (UCP2) -866G>A gene polymorphism (rs659366) with nonalcoholic fatty liver disease (NAFLD). Methods: We performed a case-control study with a cohort of 75 patients with NAFLD (of Iranian ethnicity) and 76 healthy individuals of Iranian ethnicity. The UCP2 -866G>A polymorphism (rs659366) was determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: Patients with AA and AG genotypes were 71\% and 68\%, respectively, more likely to have NAFLD, compared with individuals with the GG genotype (reference group). In subjects with a GG genotype, serum triglyceride (TG) concentration was significantly higher in patients with NAFLD (P=.04). Serum alanine aminotransferase (ALT) concentrations in all 3 genotypes and serum aspartate aminotransferase (AST) concentrations in AG and GG genotypes of UCP2 gene polymorphism were significantly higher in patients (P <.05). Conclusion: Our results revealed a modest modifier effect of -866G>A UCP2 polymorphism in patients with NAFLD.",

keywords = "-866G>A polymorphism, Anthropometric indices, Biochemical parameters, Nonalcoholic fatty liver disease (NAFLD), Uncoupling protein 2 (UCP2) gene",

author = "Fatemeh Mohseni and Safar Farajnia and Farhangi, \{Mahdieh Abbasalizad\} and Manouchehr Khoshbaten and Jafarabadi, \{Mohammad Asghari\}",

year = "2017",

month = feb,

doi = "10.1093/labmed/lmw052",

language = "English",

volume = "48",

pages = "65--72",

journal = "Laboratory Medicine",

issn = "0007-5027",

publisher = "Oxford University Press, USA",

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T1 - Association of UCP2 -866G>A polymorphism with nonalcoholic fatty liver disease in patients from North-West of Iran

AU - Mohseni, Fatemeh

AU - Farajnia, Safar

AU - Farhangi, Mahdieh Abbasalizad

AU - Khoshbaten, Manouchehr

AU - Jafarabadi, Mohammad Asghari

PY - 2017/2

Y1 - 2017/2

N2 - Objective: To investigate the association of uncoupling protein-2 (UCP2) -866G>A gene polymorphism (rs659366) with nonalcoholic fatty liver disease (NAFLD). Methods: We performed a case-control study with a cohort of 75 patients with NAFLD (of Iranian ethnicity) and 76 healthy individuals of Iranian ethnicity. The UCP2 -866G>A polymorphism (rs659366) was determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: Patients with AA and AG genotypes were 71% and 68%, respectively, more likely to have NAFLD, compared with individuals with the GG genotype (reference group). In subjects with a GG genotype, serum triglyceride (TG) concentration was significantly higher in patients with NAFLD (P=.04). Serum alanine aminotransferase (ALT) concentrations in all 3 genotypes and serum aspartate aminotransferase (AST) concentrations in AG and GG genotypes of UCP2 gene polymorphism were significantly higher in patients (P <.05). Conclusion: Our results revealed a modest modifier effect of -866G>A UCP2 polymorphism in patients with NAFLD.

AB - Objective: To investigate the association of uncoupling protein-2 (UCP2) -866G>A gene polymorphism (rs659366) with nonalcoholic fatty liver disease (NAFLD). Methods: We performed a case-control study with a cohort of 75 patients with NAFLD (of Iranian ethnicity) and 76 healthy individuals of Iranian ethnicity. The UCP2 -866G>A polymorphism (rs659366) was determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: Patients with AA and AG genotypes were 71% and 68%, respectively, more likely to have NAFLD, compared with individuals with the GG genotype (reference group). In subjects with a GG genotype, serum triglyceride (TG) concentration was significantly higher in patients with NAFLD (P=.04). Serum alanine aminotransferase (ALT) concentrations in all 3 genotypes and serum aspartate aminotransferase (AST) concentrations in AG and GG genotypes of UCP2 gene polymorphism were significantly higher in patients (P <.05). Conclusion: Our results revealed a modest modifier effect of -866G>A UCP2 polymorphism in patients with NAFLD.

KW - -866G>A polymorphism

KW - Anthropometric indices

KW - Biochemical parameters

KW - Nonalcoholic fatty liver disease (NAFLD)

KW - Uncoupling protein 2 (UCP2) gene

UR - https://www.scopus.com/pages/publications/85019953587

U2 - 10.1093/labmed/lmw052

DO - 10.1093/labmed/lmw052

M3 - Article

C2 - 27794526

AN - SCOPUS:85019953587

SN - 0007-5027

VL - 48

SP - 65

EP - 72

JO - Laboratory Medicine

JF - Laboratory Medicine

IS - 1

ER -

Association of UCP2 -866G>A polymorphism with nonalcoholic fatty liver disease in patients from North-West of Iran

Abstract

Keywords

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