Association of the 480 bp DAT1 allele with methylphenidate response in a sample of Irish children with ADHD

Aiveen Kirley, Naomi Lowe, Ziarih Hawi, Celine Mullins, Grainne Daly, Irwin Waldman, Mary McCarron, Deirdre O'Donnell, Michael Fitzgerald, Michael Gill

Research output: Contribution to journalArticleResearchpeer-review

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Abstract

Several studies have implicated the dopamine transporter gene (DAT1) as conferring susceptibility to attention deficit hyperactivity disorder (ADHD), in particular, a VNTR situated at the 3′ end of the gene. In addition, the 10-repeat VNTR allele associated with ADHD has been reported to be associated with an over-active transporter protein (DAT). Thus children possessing this variant might be particularly responsive to methylphenidate, a drug known to act by blocking DAT. We have examined this hypothesis and now report an association between the 10-repeat VNTR DAT1 polymorphism and retrospectively rated methylphenidate response in a sample of 119 Irish children with ADHD (ξ2 = 7.918, df = 1, P = 0.005). Our findings suggest a role for the 10-repeat DAT1 risk allele in medication response and may help to predict positive clinical outcome in ADHD.

Original languageEnglish
Pages (from-to)50-54
Number of pages5
JournalAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume121 B
Issue number1
Publication statusPublished - 15 Aug 2003
Externally publishedYes

Keywords

  • Attention deficit hyperactivity disorder (ADHD)
  • Dopamine transporter gene (DAT1)
  • Drug response
  • Methylphenidate
  • Transmission disequilibrium test (TDT)

Cite this

Kirley, Aiveen ; Lowe, Naomi ; Hawi, Ziarih ; Mullins, Celine ; Daly, Grainne ; Waldman, Irwin ; McCarron, Mary ; O'Donnell, Deirdre ; Fitzgerald, Michael ; Gill, Michael. / Association of the 480 bp DAT1 allele with methylphenidate response in a sample of Irish children with ADHD. In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2003 ; Vol. 121 B, No. 1. pp. 50-54.
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abstract = "Several studies have implicated the dopamine transporter gene (DAT1) as conferring susceptibility to attention deficit hyperactivity disorder (ADHD), in particular, a VNTR situated at the 3′ end of the gene. In addition, the 10-repeat VNTR allele associated with ADHD has been reported to be associated with an over-active transporter protein (DAT). Thus children possessing this variant might be particularly responsive to methylphenidate, a drug known to act by blocking DAT. We have examined this hypothesis and now report an association between the 10-repeat VNTR DAT1 polymorphism and retrospectively rated methylphenidate response in a sample of 119 Irish children with ADHD (ξ2 = 7.918, df = 1, P = 0.005). Our findings suggest a role for the 10-repeat DAT1 risk allele in medication response and may help to predict positive clinical outcome in ADHD.",
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Kirley, A, Lowe, N, Hawi, Z, Mullins, C, Daly, G, Waldman, I, McCarron, M, O'Donnell, D, Fitzgerald, M & Gill, M 2003, 'Association of the 480 bp DAT1 allele with methylphenidate response in a sample of Irish children with ADHD', American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, vol. 121 B, no. 1, pp. 50-54.

Association of the 480 bp DAT1 allele with methylphenidate response in a sample of Irish children with ADHD. / Kirley, Aiveen; Lowe, Naomi; Hawi, Ziarih; Mullins, Celine; Daly, Grainne; Waldman, Irwin; McCarron, Mary; O'Donnell, Deirdre; Fitzgerald, Michael; Gill, Michael.

In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol. 121 B, No. 1, 15.08.2003, p. 50-54.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Kirley, Aiveen

AU - Lowe, Naomi

AU - Hawi, Ziarih

AU - Mullins, Celine

AU - Daly, Grainne

AU - Waldman, Irwin

AU - McCarron, Mary

AU - O'Donnell, Deirdre

AU - Fitzgerald, Michael

AU - Gill, Michael

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