TY - JOUR
T1 - Association of the 480 bp DAT1 allele with methylphenidate response in a sample of Irish children with ADHD
AU - Kirley, Aiveen
AU - Lowe, Naomi
AU - Hawi, Ziarih
AU - Mullins, Celine
AU - Daly, Grainne
AU - Waldman, Irwin
AU - McCarron, Mary
AU - O'Donnell, Deirdre
AU - Fitzgerald, Michael
AU - Gill, Michael
PY - 2003/8/15
Y1 - 2003/8/15
N2 - Several studies have implicated the dopamine transporter gene (DAT1) as conferring susceptibility to attention deficit hyperactivity disorder (ADHD), in particular, a VNTR situated at the 3′ end of the gene. In addition, the 10-repeat VNTR allele associated with ADHD has been reported to be associated with an over-active transporter protein (DAT). Thus children possessing this variant might be particularly responsive to methylphenidate, a drug known to act by blocking DAT. We have examined this hypothesis and now report an association between the 10-repeat VNTR DAT1 polymorphism and retrospectively rated methylphenidate response in a sample of 119 Irish children with ADHD (ξ2 = 7.918, df = 1, P = 0.005). Our findings suggest a role for the 10-repeat DAT1 risk allele in medication response and may help to predict positive clinical outcome in ADHD.
AB - Several studies have implicated the dopamine transporter gene (DAT1) as conferring susceptibility to attention deficit hyperactivity disorder (ADHD), in particular, a VNTR situated at the 3′ end of the gene. In addition, the 10-repeat VNTR allele associated with ADHD has been reported to be associated with an over-active transporter protein (DAT). Thus children possessing this variant might be particularly responsive to methylphenidate, a drug known to act by blocking DAT. We have examined this hypothesis and now report an association between the 10-repeat VNTR DAT1 polymorphism and retrospectively rated methylphenidate response in a sample of 119 Irish children with ADHD (ξ2 = 7.918, df = 1, P = 0.005). Our findings suggest a role for the 10-repeat DAT1 risk allele in medication response and may help to predict positive clinical outcome in ADHD.
KW - Attention deficit hyperactivity disorder (ADHD)
KW - Dopamine transporter gene (DAT1)
KW - Drug response
KW - Methylphenidate
KW - Transmission disequilibrium test (TDT)
UR - http://www.scopus.com/inward/record.url?scp=0041819651&partnerID=8YFLogxK
M3 - Article
C2 - 12898575
AN - SCOPUS:0041819651
SN - 1552-4841
VL - 121 B
SP - 50
EP - 54
JO - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
IS - 1
ER -