Association of pulsatile and mean cerebral blood flow velocity with age and neuropsychological performance

Matthew P Pase, Natalie Grima, Con Stough, Andrew B Scholey, Andrew Pipingas

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Abstract

Low cerebral blood flow velocity is associated with cognitive decline. However, the association between pulsatile brain blood flow velocity and cognition has not been investigated. High pulsatile hemodynamic stress in the brain may impair cognitive function through damage to small cerebral vessels. The current objective was to examine the cross-sectional association of pulsatile and mean cerebral blood flow velocity with age and neuropsychological performance. We also examined whether cerebral blood flow velocity was associated with aortic pulse pressure, a measure of arterial ageing and aortic stiffness. Cerebral blood flow velocity was measured in the middle cerebral artery using Transcranial Doppler Ultrasonography (TDU) while neuropsychological performance was measured using a computerized cognitive test battery. Aortic pulse pressure was non-invasively derived from applanation tonometry of the radial artery. The sample comprised 160 healthy adults aged 50-70. years. Results indicated that increasing age correlated with lower mean ( r= - 0.23, p
Original languageEnglish
Pages (from-to)23 - 27
Number of pages5
JournalPhysiology and Behavior
Volume130
DOIs
Publication statusPublished - 2014

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