Association of low vitamin D with high disease activity in an Australian systemic lupus erythematosus cohort

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Abstract

BACKGROUND: Vitamin D status varies with geographic location and no studies of vitamin D in systemic lupus erythematosus (SLE) have been reported in the Southern Hemisphere. OBJECTIVES: To assess the prevalence of vitamin D deficiency in an Australian SLE cohort, and its relationship with disease activity. METHODS: Data were collected prospectively on 119 consecutive patients with SLE in the Monash Lupus Clinic in Melbourne, Australia, between January 2007 and January 2013. Patients had simultaneous serum 25-hydroxyvitamin D concentration and disease activity (SLEDAI-2K) recorded. Statistical methods were used to determine the correlation of serum vitamin D level and disease activity both at baseline and at a subsequent time point. Adjustments were made for the use of glucocorticoids, immunosuppressants and vitamin D supplementation. RESULTS: Vitamin D deficiency (10) at the subsequent time point (univariable OR 3.1, 95 CI 1.4 to 6.8, p=0.004). CONCLUSIONS: In Australian patients with SLE, low vitamin D was associated with a higher disease activity and an increase in serum vitamin D was associated with reduced disease activity over time. The therapeutic effect of vitamin D in SLE should be further assessed in interventional studies.
Original languageEnglish
Pages (from-to)1 - 7
Number of pages7
JournalLupus Science and Medicine
Volume2
Issue number1
DOIs
Publication statusPublished - 2015

Cite this

@article{8631b6b567264e808c3c27fd353da165,
title = "Association of low vitamin D with high disease activity in an Australian systemic lupus erythematosus cohort",
abstract = "BACKGROUND: Vitamin D status varies with geographic location and no studies of vitamin D in systemic lupus erythematosus (SLE) have been reported in the Southern Hemisphere. OBJECTIVES: To assess the prevalence of vitamin D deficiency in an Australian SLE cohort, and its relationship with disease activity. METHODS: Data were collected prospectively on 119 consecutive patients with SLE in the Monash Lupus Clinic in Melbourne, Australia, between January 2007 and January 2013. Patients had simultaneous serum 25-hydroxyvitamin D concentration and disease activity (SLEDAI-2K) recorded. Statistical methods were used to determine the correlation of serum vitamin D level and disease activity both at baseline and at a subsequent time point. Adjustments were made for the use of glucocorticoids, immunosuppressants and vitamin D supplementation. RESULTS: Vitamin D deficiency (10) at the subsequent time point (univariable OR 3.1, 95 CI 1.4 to 6.8, p=0.004). CONCLUSIONS: In Australian patients with SLE, low vitamin D was associated with a higher disease activity and an increase in serum vitamin D was associated with reduced disease activity over time. The therapeutic effect of vitamin D in SLE should be further assessed in interventional studies.",
author = "Yap, {Kristy Su-ying} and Northcott, {Melissa Jane} and Alberta Hoi and Morand, {Eric Francis} and Mandana Nikpour",
year = "2015",
doi = "10.1136/lupus-2014-000064",
language = "English",
volume = "2",
pages = "1 -- 7",
journal = "Lupus Science and Medicine",
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Association of low vitamin D with high disease activity in an Australian systemic lupus erythematosus cohort. / Yap, Kristy Su-ying; Northcott, Melissa Jane; Hoi, Alberta; Morand, Eric Francis; Nikpour, Mandana.

In: Lupus Science and Medicine, Vol. 2, No. 1, 2015, p. 1 - 7.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Association of low vitamin D with high disease activity in an Australian systemic lupus erythematosus cohort

AU - Yap, Kristy Su-ying

AU - Northcott, Melissa Jane

AU - Hoi, Alberta

AU - Morand, Eric Francis

AU - Nikpour, Mandana

PY - 2015

Y1 - 2015

N2 - BACKGROUND: Vitamin D status varies with geographic location and no studies of vitamin D in systemic lupus erythematosus (SLE) have been reported in the Southern Hemisphere. OBJECTIVES: To assess the prevalence of vitamin D deficiency in an Australian SLE cohort, and its relationship with disease activity. METHODS: Data were collected prospectively on 119 consecutive patients with SLE in the Monash Lupus Clinic in Melbourne, Australia, between January 2007 and January 2013. Patients had simultaneous serum 25-hydroxyvitamin D concentration and disease activity (SLEDAI-2K) recorded. Statistical methods were used to determine the correlation of serum vitamin D level and disease activity both at baseline and at a subsequent time point. Adjustments were made for the use of glucocorticoids, immunosuppressants and vitamin D supplementation. RESULTS: Vitamin D deficiency (10) at the subsequent time point (univariable OR 3.1, 95 CI 1.4 to 6.8, p=0.004). CONCLUSIONS: In Australian patients with SLE, low vitamin D was associated with a higher disease activity and an increase in serum vitamin D was associated with reduced disease activity over time. The therapeutic effect of vitamin D in SLE should be further assessed in interventional studies.

AB - BACKGROUND: Vitamin D status varies with geographic location and no studies of vitamin D in systemic lupus erythematosus (SLE) have been reported in the Southern Hemisphere. OBJECTIVES: To assess the prevalence of vitamin D deficiency in an Australian SLE cohort, and its relationship with disease activity. METHODS: Data were collected prospectively on 119 consecutive patients with SLE in the Monash Lupus Clinic in Melbourne, Australia, between January 2007 and January 2013. Patients had simultaneous serum 25-hydroxyvitamin D concentration and disease activity (SLEDAI-2K) recorded. Statistical methods were used to determine the correlation of serum vitamin D level and disease activity both at baseline and at a subsequent time point. Adjustments were made for the use of glucocorticoids, immunosuppressants and vitamin D supplementation. RESULTS: Vitamin D deficiency (10) at the subsequent time point (univariable OR 3.1, 95 CI 1.4 to 6.8, p=0.004). CONCLUSIONS: In Australian patients with SLE, low vitamin D was associated with a higher disease activity and an increase in serum vitamin D was associated with reduced disease activity over time. The therapeutic effect of vitamin D in SLE should be further assessed in interventional studies.

UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395813/pdf/lupus-2014-000064.pdf

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DO - 10.1136/lupus-2014-000064

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JO - Lupus Science and Medicine

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SN - 2053-8790

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