Association of long-term exposure to ambient air pollutants with cardiac structure and cardiovascular function in Chinese adults

Junjie Hu, Gongbo Chen, Shanshan Li, Yuming Guo, Junchao Duan, Zhiwei Sun

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Epidemiological evidence increasingly suggests that air pollutants are intimately associated with the incidence and mortality of cardiovascular diseases (CVDs). However, studies on the association between chronic exposure to air pollutants and changes in left cardiac function and structure are limited. In our cross-sectional study, 3145 participants were enrolled from 6 provinces to explore the relationship between long-term air pollutants, cardiac structure, and cardiovascular function (e.g., blood lipids, blood pressure and pulse) in Chinese adults. Our study showed that exposure to five pollutants (NO2, O3, PM1, PM2.5 and PM10) was associated with reduced left ventricular systolic function based on EF and SV parameters. These pollutants were also associated with increased pulses, where smaller particle sizes correlated significantly with pulses. Second, except for O3, four pollutants were associated with decreased left ventricular diastolic parameters LVIDd and EDV and increased cardiac structural parameter IVSd. In addition, exposures to NO2, O3 and PM10 were positively correlated with triglycerides in blood lipids. Overall, this study showed that chronic pollutant exposure is strongly associated with impaired left ventricular function in Chinese adults.

Original languageEnglish
Article number114382
Number of pages7
JournalEcotoxicology and Environmental Safety
Publication statusPublished - 1 Jan 2023


  • Blood lipids
  • Cardiac function
  • NO
  • O
  • PM
  • Pulse

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